Establishment of bone quality improvement therapy using intelligent artificial bone

• Project/Area Number: 15K11160
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Hiroshima University
• Principal Investigator: DOI KAZUYA 広島大学, 医歯薬保健学研究科(歯), 助教 (80444686)
• Co-Investigator(Kenkyū-buntansha): 岡崎 洋平 広島大学, 病院(歯), 助教 (00706898) ; 日浅 恭 広島大学, 病院(歯), 講師 (60304432)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: PTH / 骨粗鬆症 / 骨質

Outline of Final Research Achievements

In this study, bone quality improvement therapy using combination methods of intelligent arterial bone: polyphosphate integrated porous HA and intermittent PTH administration was assessment under conditions of reduced bone quality and metabolism. The combination methods indicated the promotion of osteoblast activation, enhancement bone formation and establishment implant stability: preferable primary stability and achievement osseointegration in rabbit osteoporosis model.

Research Products

• [Journal Article] A stability evaluation of a novel titanium dental implant/interconnected porous hydroxyapatite complex under functional loading conditions (2017)
  • Author(s): Doi K, Kubo T, Kajihara S, Makihara Y, Oue H, Oki Y, Perrotti V, Piattelli A, Akagawa Y, Tsuga K
  • Journal Title: Dent. Mater. J. Volume: 36 Issue: 5 Pages: 647-653
  • DOI: 10.4012/dmj.2016-346
  • NAID: 130006100237
  • ISSN: 0287-4547, 1881-1361
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite (2017)
  • Author(s): Makihara Y, Doi K, Oki Y, Kobatake R, Kubo T, Tsuga K.
  • Journal Title: J. Hard Tissue Biology. Volume: 26 Issue: 4 Pages: 393-398
  • DOI: 10.2485/jhtb.26.393
  • NAID: 130006832131
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access
• [Journal Article] Effects of intermittent continual administration of parathyroid hormone on implant stability in the presence of osteoporosis: an in vivo study using resonance frequency analysis in a rabbit model (2017)
  • Author(s): Oki Y, Doi K, Makihara Y, Kobatake R, Kubo T, Tsuga K.
  • Journal Title: Journal of Applied Oral Science Volume: 25 Pages: 498-505
  • DOI: 10.1590/1678-7757-2016-0561
  • Peer Reviewed / Open Access
• [Journal Article] Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone- reduced rabbit model. (2016)
  • Author(s): Oki Y, Doi K, Makihara Y, Kubo T，Oue H, Tsuga K.
  • Journal Title: Journal of Oral Science Volume: -
  • NAID: 130005158879
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous hydroxyapatite. (2016)
  • Author(s): Doi K, Kubo T, Makihara Y, Oue H, Morita K, Oki Y, Kajihara S, Tsuga K.
  • Journal Title: Journal of Applied Oral Science Volume: -
  • Peer Reviewed / Open Access
• [Presentation] 副甲状腺ホルモンの間歇投与がステロイド性骨粗鬆症モデルにおけるオッセオインテグレーションの獲得に及ぼす影響 (2017)
  • Author(s): 沖 佳史，久保 隆靖，土井 一矢，牧原 勇介，津賀 一弘
  • Organizer: 第47回（社）日本口腔インプラント学会学術大会
• [Presentation] Evaluation of Implant Stability in Implant/Interconnected Porous Hydroxyapatite Complex Under Functional Loading Location (2016)
  • Author(s): Doi K., Makihara Y., Oue H., Morita K., Kubo T., Tsuga K
  • Organizer: The 94th General Session and Exihibition of the International Association for Dental Research
  • Place of Presentation: Seouｌ, Korea
  • Year and Date: 2016-06-23
  • Int'l Joint Research
• [Presentation] Intermittent Parathyroid Hormone Administration is Effective to Achieve Favourable Primary Stability and Osseointegration in Rabbit Osteoporosis Model (2016)
  • Author(s): Oki Y., Doi K., Makihara Y., Kubo T., Tsuga K
  • Organizer: The 11th Scientific Meeting of the Asian Academy of Osseointegration
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2016-06-04
  • Int'l Joint Research
• [Presentation] Intermittent parathyroid hormone administration enhances primary stability and osseointegration on glucocorticoid induced osteoporosis (2015)
  • Author(s): Doi K., Kubo T., Oki Y., Makihara Y., Tsuga K
  • Organizer: 広島カンファレンス 平和セミナー2015
  • Place of Presentation: 広島
  • Year and Date: 2015-10-26
  • Invited
• [Presentation] Effect of intermittent parathyroid hormone administration on osseointegration aspects in rabbit osteoporosis model (2015)
  • Author(s): Oki Y., Doi K., Makihara Y., Kubo T., Tsuga K
  • Organizer: 6th Hiroshima Conference on Education and Science in Dentistry
  • Place of Presentation: Hiroshima
  • Year and Date: 2015-10-23
  • Int'l Joint Research
• [Presentation] Effect of intermittent parathyroid hormone (PTH) administration on osseointegration aspects in rabbit osteoporosis model (2015)
  • Author(s): Doi K., Kubo T., Oki Y., Makihara Y., Tsuga K
  • Organizer: The 24rd European Association for Osseointegration
  • Place of Presentation: Stockholm（Sweden）
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] 副甲状腺ホルモン間歇投与がインプラントの初期固定および骨支持に及ぼす影響－骨質低下ラビットモデルでの検討 (2015)
  • Author(s): 沖 佳史，土井一矢，牧原勇介，久保隆靖，津賀一弘
  • Organizer: 第45回公益社団法人日本口腔インプラント学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2015-09-21