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Establishment of bone quality improvement therapy using intelligent artificial bone

Research Project

Project/Area Number 15K11160
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionHiroshima University

Principal Investigator

DOI KAZUYA  広島大学, 医歯薬保健学研究科(歯), 助教 (80444686)

Co-Investigator(Kenkyū-buntansha) 岡崎 洋平  広島大学, 病院(歯), 助教 (00706898)
日浅 恭  広島大学, 病院(歯), 講師 (60304432)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsPTH / 骨粗鬆症 / 骨質
Outline of Final Research Achievements

In this study, bone quality improvement therapy using combination methods of intelligent arterial bone: polyphosphate integrated porous HA and intermittent PTH administration was assessment under conditions of reduced bone quality and metabolism. The combination methods indicated the promotion of osteoblast activation, enhancement bone formation and establishment implant stability: preferable primary stability and achievement osseointegration in rabbit osteoporosis model.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] A stability evaluation of a novel titanium dental implant/interconnected porous hydroxyapatite complex under functional loading conditions2017

    • Author(s)
      Doi K, Kubo T, Kajihara S, Makihara Y, Oue H, Oki Y, Perrotti V, Piattelli A, Akagawa Y, Tsuga K
    • Journal Title

      Dental Materials Journal

      Volume: 36 Issue: 5 Pages: 647-653

    • DOI

      10.4012/dmj.2016-346

    • NAID

      130006100237

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stability of Implants Placed in Bone Reconstructed with Block-type Interconnected Porous Hydroxyapatite2017

    • Author(s)
      Makihara Y, Doi K, Oki Y, Kobatake R, Kubo T, Tsuga K.
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 26 Issue: 4 Pages: 393-398

    • DOI

      10.2485/jhtb.26.393

    • NAID

      130006832131

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of intermittent continual administration of parathyroid hormone on implant stability in the presence of osteoporosis: an in vivo study using resonance frequency analysis in a rabbit model.2017

    • Author(s)
      Oki Y, Doi K, Makihara Y, Kobatake R, Kubo T, Tsuga K.
    • Journal Title

      J Appl Oral Sci

      Volume: 25 Issue: 5 Pages: 498-505

    • DOI

      10.1590/1678-7757-2016-0561

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone- reduced rabbit model.2016

    • Author(s)
      Oki Y, Doi K, Makihara Y, Kubo T,Oue H, Tsuga K.
    • Journal Title

      Journal of Oral Science

      Volume: -

    • NAID

      130005158879

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous hydroxyapatite.2016

    • Author(s)
      Doi K, Kubo T, Makihara Y, Oue H, Morita K, Oki Y, Kajihara S, Tsuga K.
    • Journal Title

      Journal of Applied Oral Science

      Volume: -

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 副甲状腺ホルモンの間歇投与がステロイド性骨粗鬆症モデルにおけるオッセオインテグレーションの獲得に及ぼす影響2017

    • Author(s)
      沖 佳史,久保 隆靖,土井 一矢,牧原 勇介,津賀 一弘
    • Organizer
      第47回(社)日本口腔インプラント学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of Implant Stability in Implant/Interconnected Porous Hydroxyapatite Complex Under Functional Loading Location2016

    • Author(s)
      Doi K., Makihara Y., Oue H., Morita K., Kubo T., Tsuga K
    • Organizer
      The 94th General Session and Exihibition of the International Association for Dental Research
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intermittent Parathyroid Hormone Administration is Effective to Achieve Favourable Primary Stability and Osseointegration in Rabbit Osteoporosis Model2016

    • Author(s)
      Oki Y., Doi K., Makihara Y., Kubo T., Tsuga K
    • Organizer
      The 11th Scientific Meeting of the Asian Academy of Osseointegration
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intermittent parathyroid hormone administration enhances primary stability and osseointegration on glucocorticoid induced osteoporosis2015

    • Author(s)
      Doi K., Kubo T., Oki Y., Makihara Y., Tsuga K
    • Organizer
      広島カンファレンス 平和セミナー2015
    • Place of Presentation
      広島
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Effect of intermittent parathyroid hormone administration on osseointegration aspects in rabbit osteoporosis model2015

    • Author(s)
      Oki Y., Doi K., Makihara Y., Kubo T., Tsuga K
    • Organizer
      6th Hiroshima Conference on Education and Science in Dentistry
    • Place of Presentation
      Hiroshima
    • Year and Date
      2015-10-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of intermittent parathyroid hormone (PTH) administration on osseointegration aspects in rabbit osteoporosis model2015

    • Author(s)
      Doi K., Kubo T., Oki Y., Makihara Y., Tsuga K
    • Organizer
      The 24rd European Association for Osseointegration
    • Place of Presentation
      Stockholm(Sweden)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 副甲状腺ホルモン間歇投与がインプラントの初期固定および骨支持に及ぼす影響-骨質低下ラビットモデルでの検討2015

    • Author(s)
      沖 佳史,土井一矢,牧原勇介,久保隆靖,津賀一弘
    • Organizer
      第45回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-09-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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