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Investigation of inhibitors for bone resorption caused by excess occlusal load

Research Project

Project/Area Number 15K11162
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu University

Principal Investigator

MAKHIRA Seicho  九州大学, 歯学研究院, 准教授 (80304450)

Co-Investigator(Kenkyū-buntansha) 峯 裕一  九州大学, 医学研究院, 講師 (60605989)
諸井 亮司  九州大学, 大学病院, 助教 (70325471)
篠原 義憲  九州大学, 歯学研究院, 共同研究員 (00423533)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsメカニカルストレス / ephrin / Eph / 圧縮 / ephori / 伸展
Outline of Final Research Achievements

The communication between ephrin/Eph family was recently shown to be involved in cell differentiation under mechanical stress. To understand the roles of ephrinB2 and EphB4 in alveolar bone under initial mechanical stress of dental implant replacement, in vivo experiment was carried out. The mini-implant surface immobilised with ephrinB2-Fc recovered the suppression of Osterix. Taken together, the present results suggest that increased binding of ephrinB2 and EphB4 in osteoblast cells exposed to initial mechanical force, especially compressive force, may be involved in alveolar bone recovery.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2018 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Roles of EphrinB2 and EphB4 in Alveolar Bone under Initial Compressive Mechanical Stress of Dental Implant Replacement2018

    • Author(s)
      Kazuyuki Kitamura, Yuichi Mine, Wataru Koto, Takanori Wachi, Yoshinori Shinohara, Seicho Makihira, Kiyoshi Koyano
    • Journal Title

      Journal of Dentistry & Oral Disorders

      Volume: 4 Pages: 1-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] フッ素化合物歯面塗布剤によるチタンの腐食と溶出2016

    • Author(s)
      和智貴紀 首藤崇裕 篠原義憲 的野良就 牧平清超
    • Journal Title

      日本口腔インプラント学会

      Volume: 29 Pages: 12-19

    • NAID

      130005150160

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increase in receptor activator of nuclear factor κB ligand/osteoprotegerin ratio in peri-implant gingiva exposed to Porphyromonas gingivalis lipopolysaccharide2016

    • Author(s)
      Takahiro Shuto, Takanori Wachi, Yoshinori Shinohara, Hiroki Nikawa, Seicho Makihira
    • Journal Title

      Journal of Dental Sciences

      Volume: 11 Issue: 1 Pages: 8-16

    • DOI

      10.1016/j.jds.2015.10.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] インプラント埋入時のメカニカルストレスによるEphとephrinの発現変化2016

    • Author(s)
      北村和幸 篠原義憲 和智貴紀 古藤航 栗田賢一 寺崎崇人 牧平清超
    • Organizer
      日本補綴歯科学会 第125回学術大会
    • Place of Presentation
      金沢市
    • Year and Date
      2016-07-09
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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