| Project/Area Number |
15K11170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 祐介 九州歯科大学, 歯学部, 助教 (00611287)
向坊 太郎 九州歯科大学, 歯学部, 助教 (50635117)
細川 隆司 九州歯科大学, 歯学部, 教授 (60211546)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | コラーゲン架橋 / 骨質 / ナノインデンテーション / インプラント / ペントシジン |
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| Outline of Final Research Achievements |
The objective of this study was to clarify the loss of bone toughening mechanism with aging processes mainly associated with AGEs by means of multi-scale mechanical testing, such as three-point bending and nanoindentation tests. A three-point bending test revealed a greater reduction in femoral fracture resistance in methionine-rich diet rabbits despite the higher maximum and breaking forces than those of normal diet rabbits. The strain-dependent stiffening was likely associated with strain-energy transfer to the superior normal diet cross-linked bone matrix network, while the reduction in the enzymatic crosslinking matrix in bone samples from the methionine-rich diet rabbits likely diminished the intrinsic bone toughening mechanism.
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