Development of Dynamic GBR using bioactive shape memorial membrane

• Project/Area Number: 15K11209
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tohoku University
• Principal Investigator: YAMAUCHI KENSUKE 東北大学, 歯学研究科, 准教授 (10364150)
• Co-Investigator(Kenkyū-buntansha): 高田 雄京 東北大学, 歯学研究科, 准教授 (10206766) ; 清水 良央 東北大学, 歯学研究科, 助教 (30302152) ; 高橋 哲 東北大学, 歯学研究科, 教授 (60226850)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 骨造成 / 骨増生 / Dynamic GBR / 骨延長 / インプラント / GBR / guided bone regeneration / 骨膜伸展骨形成法

Outline of Final Research Achievements

Newly formed bone was observed at the gap between SMA mesh device and original bone surface, and decorticaton procedure enhanced early bone regeneration from original bone surface. This technique appears to be a promising clinical alternative as alveolar bone augmentation and suggests the new concept of “dynamic GBR” for the atrophic alveolar bone.

Research Products

• [Journal Article] Cortical Bone Repositioning Technique for Horizontal Alveolar Bone Augmentation: A Case Series (2018)
  • Author(s): Yamauchi Kensuke、Nogami Shinnosuke、Kataoka Yoshihiro、Koyama Shigeto、Lethaus Bernd、Takahashi Tetsu
  • Journal Title: The International Journal of Periodontics and Restorative Dentistry Volume: 未定 Issue: 5 Pages: 691-697
  • DOI: 10.11607/prd.2839
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Timed-release system for periosteal expansion osteogenesis using NiTi mesh and absorbable material in the rabbit calvaria (2016)
  • Author(s): Yamauchi K Nogami S Martinez-de la Cruz G Hirayama B Shimizu Y Kumamoto H Lethaus B Kessler P Takahashi T
  • Journal Title: J Craniomaxillofac Surg Volume: 44 Issue: 9 Pages: 1366-1372
  • DOI: 10.1016/j.jcms.2016.06.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Osteogenesis due to periosteal elevation with degradable and non-degradable devices in Go;ttingen minipig (2016)
  • Author(s): Dominik Dziewiecki, Sander van de Loo, Felix Gremse, Anita Kloss-Brandstter, Frank Kloss, Vincent Offermanns, Kensuke Yamauchi, Peter Kessler, Bernd Lethaus
  • Journal Title: Journal of Craniomaxillofacial Surgery Volume: 44 Issue: 3 Pages: 318-324
  • DOI: 10.1016/j.jcms.2015.12.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Experimental comparison between tractional and compressive stress on temporomandibular joint (2016)
  • Author(s): Nogami S, Yamauchi K, Shimizu Y, Hirayama B, Kumasaka A, Iikubo M, Kumamoto H, Takahashi T
  • Journal Title: Oral Disease Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Cortical bone repositioning for horizontal alveolar bone augmentation; A case series (2016)
  • Author(s): Yamauchi K, Nogami S, Kataoka Y, Koyama S, Lethaus B, Takahashi T
  • Journal Title: Journal of Periodontal & Restrative Dentistry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Ultrasound-guided fine-needle aspiration cytology as a diagnostic tool in comparison to ultrasound and MRI for staging in oral- and oropharyngeal squamous cell tumors (2016)
  • Author(s): Cyriel Souren, Anita Kloss-Brandtter, Annika Stadler, Kross Kenneth, Kensuke Yamauchi, Dominik Ketelsen, Peter Kessler, Bernd Lethaus
  • Journal Title: Journal of Craniomaxillofacial Surgery Volume: 44 Issue: 2 Pages: 197-201
  • DOI: 10.1016/j.jcms.2015.11.003
• [Journal Article] Osteogenesis due to periosteal elevation with degradable and non-degradable devices in Goettingen minipig (2016)
  • Author(s): Dominik Dziewiecki, Sander van de Loo, Felix Gremse, Anita Kloss-Brandstatter, Frank Kloss, Vincent Offermanns, Kensuke Yamauchi, Peter Kessler, Bernd Lethaus
  • Journal Title: Journal of Craniomaxillofacial Surgery Volume: 44 Pages: 318-324
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cortical bone repositioning for horizontal alveolar bone augmentation; A case series (2016)
  • Author(s): Kensuke Yamauchi, Shinnosuke Nogami, Yoshihiro Kataoka, Shigeto Koyama, Bernd Lethaus, Tetsu Takahashi
  • Journal Title: International Journal of Periodontal & Restrative Dentistry Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The effect of decortication for periosteal expansion osteogenesis using shape memory alloy device. (2015)
  • Author(s): Kensuke Yamauchi, Shinnosuke Nogami, Kenko Tanaka, Sou Yokota, Yoshinaka Shimizu, Hiroyasu Kanetaka, Tetsu Takahashi
  • Journal Title: Clinical Implant Dentistry and Related Research Volume: 17
  • Peer Reviewed
• [Presentation] 口腔腫瘍患者に対する広範囲顎骨支持型装置についての臨床的検討 (2017)
  • Author(s): 北村 淳，田沼 裕志，野上 晋之介,川井 忠, 樋口 景介, 宮下 仁, 橋元 亘, 森 士朗, 山内 健介,小山 重人，高橋 哲
  • Organizer: 第35回日本口腔腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 2017-01-26
• [Presentation] インプラント治療を前提とした抜歯窩温存のための意図的分割抜歯 (2016)
  • Author(s): 山内健介
  • Organizer: 第46回日本口腔インプラント学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-09-16
  • Invited
• [Presentation] Timed-release system for periosteal expansion osteogenesis using NiTi mesh and absorbable material in the rabbit calvaria. (2016)
  • Author(s): Yamauchi K, Nogami S, Shimizu Y, Takahashi T.
  • Organizer: 23th Congress of the European Association for Cranio Maxillo-Facial Surgery
  • Place of Presentation: ロンドン
  • Year and Date: 2016-09-13
  • Int'l Joint Research
• [Presentation] カスタムメイド型チタンメッシュプレートによる下顎骨再建症例の術前後軟組織評価 (2016)
  • Author(s): 山内健介、高橋 哲
  • Organizer: 第33回日本顎顔面補綴学会総会・学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2016-06-02
• [Presentation] 生体吸収材料と形状記憶合金メッシュを組み合わせた時限骨膜伸展骨形成法 (2015)
  • Author(s): 山内健介、平山聞一、マルチネス ヘラルド、野上晋之介、髙橋 哲
  • Organizer: 第60回(公社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-16
• [Presentation] 皮質骨移動術を併用した歯槽骨再生誘導療法の臨床的検討 (2015)
  • Author(s): 山内健介、野上晋之介、片岡良浩、小山重人、髙橋 哲
  • Organizer: 第45回（公社）日本口腔インプラント学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2015-09-21
• [Book] Vertical Alveolar Ridge Augmentation in Implant Dentistry: A Surgical Manual (2016)
  • Author(s): Tetsu Takahashi, Kensuke Yamauchi
  • Total Pages: 368
  • Publisher: Wiley
• [Book] Horizontal alveolar distraction osteogenesis and periosteal expansion osteogensis. (2016)
  • Author(s): Kensuke Yamauchi, Tetsu Takahashi
  • Total Pages: 340
  • Publisher: Willy-Blackwell