Bone regenerative medicine by iPS cell derived soluble paracrine factors
Project/Area Number |
15K11213
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
|
Research Institution | Niigata University (2016-2017) Nagoya University (2015) |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 骨再生 / iPS細胞 / 増殖因子 / 培養上清 / 液性因子 / エクソソーム / 成長因子 / 骨 / サイトカイン |
Outline of Final Research Achievements |
Bone regeneration by the secretomes from oral mucosa derived iPS cells and bone marrow derived mesenchymal stem cells were evaluated. We used conditioned medium (CM), CM mimicked cocktail of cytokines (CC) and exosome (Exo). CM, CC and Exo improved the migration of stem cells, angiogenesis and differentiation into osteoblast although these three did not show any statistical difference. Even in animal studies, the results of bone formation were same. These results indicated the conditioned medium and its contents will be able to substitute the current stem cell therapy in bone regenerative medicine.
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Report
(4 results)
Research Products
(17 results)