Minimally invasive treatment of periimplantitis by nonthermal irreversible electroporation

Research Project

Project/Area Number	15K11217
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Kyushu University
Principal Investigator	ESAKI DAISUKE 九州大学, 歯学研究院, 助教 (10608970)
Co-Investigator(Kenkyū-buntansha)	松下恭之九州大学, 大学病院, 准教授 (60159150) 三浦真由美九州大学, 大学病院, 学術研究員 (00404054) 古谷野潔九州大学, 歯学研究院, 教授 (50195872) 大木郷資九州大学, 大学病院, 医員 (10803463)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	インプラント周囲炎 / 殺菌 / 過硝酸 / 治療
Outline of Final Research Achievements	The purpose of this study was to investigate the bactericidal effect of Peroxynitric acid on the biofilm cultured on titanium surface. Streptococcus gordonii (ATCC 10558 ) was cultured on a titanium disc with NS, 0.025% BZC, 0.2% CHX, 4.6 mmol / L PNA, and 4.6 mmol / L of PNA whichwas left standing at 25 ° C-24 hour to inactivate bactericidal activity These seven type of chemical solution were compared with bactericidal effec . As a result of the CFU assay, in PNA, the number of bacteria was less than the detection limit at an action time of 10 seconds. Compared with other disinfectants, it was suggested that PNA is useful for sterilizing bacterially contaminated titanium surfaces.