| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We found that CEMP-1 expression was enhanced by stimulating mesenchymal stem cells with enamel matrix protein (EMD).
The expression of CEMP-1 involves the transcription factor HIF-1. We found that stimulation of periodontal ligament fibroblasts (HPDLF) with EMD raises HIF-1 transcriptional activity. One target molecule of HIF-1 is SDF-1. Since SDF-1 induces mesenchymal stem cells, we investigated its production.
We found that SDF-1 production increased when HPDLF were stimulated with EMD. Therefore, SDF-1 may promote periodontal regeneration by induction of mesenchymal stem cells. EMD and SDF-1 are expected to be applied to dental implant treatment.
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