A basic research on dental implants with periodontal tissue based on induction of cementblast differentiation
| Project/Area Number |
15K11219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKODA Kenji 鹿児島大学, 医歯学域歯学系, 助教 (70419654)
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| Co-Investigator(Kenkyū-buntansha) |
白方 良典 鹿児島大学, 医歯学域歯学系, 准教授 (60359982)
瀬名 浩太郎 鹿児島大学, 医歯学域歯学系, 助教 (60701117)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | エナメルマトリックスタンパク / SDF-1 / HIF-1 / CEMP-1 / 間葉系幹細胞 / セメント芽細胞 |
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| Outline of Final Research Achievements |
We found that CEMP-1 expression was enhanced by stimulating mesenchymal stem cells with enamel matrix protein (EMD).
The expression of CEMP-1 involves the transcription factor HIF-1. We found that stimulation of periodontal ligament fibroblasts (HPDLF) with EMD raises HIF-1 transcriptional activity. One target molecule of HIF-1 is SDF-1. Since SDF-1 induces mesenchymal stem cells, we investigated its production.
We found that SDF-1 production increased when HPDLF were stimulated with EMD. Therefore, SDF-1 may promote periodontal regeneration by induction of mesenchymal stem cells. EMD and SDF-1 are expected to be applied to dental implant treatment.
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Report
(4 results)
Research Products
(1 results)
