| Project/Area Number |
15K11230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
Li Xianqi 松本歯科大学, 歯学部, 講師 (60350831)
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| Co-Investigator(Kenkyū-buntansha) |
高田 匡基 松本歯科大学, 歯学部, 助教 (00507684)
楊 静 松本歯科大学, 総合歯科医学研究所, 講師 (50410436)
各務 秀明 松本歯科大学, 総合歯科医学研究所, 教授 (80242866)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨再生 / 炎症サイトカイン / 骨芽細胞 / 破骨細胞 / ステロイド / サイトカイン / 骨免疫 / 皮質骨由来細胞 |
|---|
| Outline of Final Research Achievements |
A bone regeneration model was established by compact bone derived cells (CBDCs) in immunocompetent mice, new bone formation was observed, the expression of inflammatory cytokine IL-4, IL-17 and Osterix were increased from 2 weeks to 4 weeks. The levels of IL-6 and TNF-α were keeps in high value as compared with nude mice. After steroid administration, early inflammatory cell infiltration and IL-4, TNF-α were decreased in the transplantation site. Even with steroid short-time administration, the expression of inflammatory cytokines such IL-6 were elevated, the apoptosis and TRAP positive cells were also increased.
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