| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We previously reported that Periodontal ligament stem cells(PDLSCs) possess the capacity to construct three-dementional blood vessel structures in vitro and can differentiate into the activated fibloblasts called myofibloblasts, which is essential for wound healing process.
Here in this study, we report that PDLSCs can construct there-dementional ligament like structure in vitro to utilizing the collagen gel contractile activity which produced when PDLSCs differented into myofibrobrasts. This constructed ligament like structure not only has dense collagen fibers that parallel to one another but possess physical strength not to break off when it pilled both sides with fingers. These promising results suggesting that PDLSCs may provide a new therapeutic application for ligament/tendon regenerative therapy.
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