• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of damage-associated molecular patterns (DAMPs) in autologous tissue-engineered cartilage and its application to regenerative medicine

Research Project

Project/Area Number 15K11236
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

Fujihara Yuko  東京大学, 医学部附属病院, 助教 (50466744)

Co-Investigator(Kenkyū-buntansha) 星 和人  東京大学, 医学部附属病院, 教授 (30344451)
Co-Investigator(Renkei-kenkyūsha) TAKATO Tsuyoshi  東京大学, 医学部附属病院, 登録診療員 (90171454)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords軟骨再生医療 / DAMPs
Outline of Final Research Achievements

To obtain stable outcomes in regenerative medicine, quality of cells for transplantation is of great importance. Potentially, cellular stress results in the release of damage-associated molecular patterns (DAMPs), and activates immunological responses, affecting the outcomes of transplanted tissues. In this study, we intentionally prepared necrotic chondrocytes to be gradually dying and releasing DAMPs, and investigated how the viability of chondrocytes could affect the maturation of tissue-engineered cartilage. It was suggested that DAMPs from necrotic chondrocytes could prompt migration of more immune cells, worsening the maturation of tissue-engineered cartilage.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Roles of macrophage migration inhibitory factor in cartilage tissue engineering.2018

    • Author(s)
      Fujihara Y, Hikita A, Takato T, Hoshi K.
    • Journal Title

      J Cell Physiol.

      Volume: 233(2) Issue: 2 Pages: 1490-1499

    • DOI

      10.1002/jcp.26036

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] T2 and apparent diffusion coefficient of MRI reflect maturation of tissue-engineered auricular cartilage subcutaneously transplanted in rats2016

    • Author(s)
      Fujihara Y, NItta N, Misawa M, Hyodo K, Shirasaki Y, Hayashi K, Kosaka R, Homma K, Numano T, Kuribayashi S, Watanabe Y, Sato J, Ohtomo K, Takato T, Hoshi K
    • Journal Title

      Tissue Eng Part C Methods

      Volume: 22(5) Issue: 5 Pages: 429-438

    • DOI

      10.1089/ten.tec.2015.0291

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Roles of macrophage migration inhibitory factor in cartilage tissue engineering.2017

    • Author(s)
      Fujihara Y, Hikita A, Hoshi K.
    • Organizer
      13th World Congress on Inflammation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of macrophages in transplantation of tissue engineered cartilage in mice.2016

    • Author(s)
      Fujihara Y, Hikita A, Takato T, Hoshi K.
    • Organizer
      International Congress of Immunology 2016
    • Place of Presentation
      Melbourne Convention and Exhibition Centre
    • Year and Date
      2016-08-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 歯科分野における再生医療2015

    • Author(s)
      藤原夕子
    • Organizer
      ニューセラミックス懇話会 第219回研究会
    • Place of Presentation
      株式会社島津製作所 関西支社 マルチホール(大阪府・大阪市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Basic and clinical research on custom-made artificial bone and tissue-engineered cartilage in oral and maxillofacial region2015

    • Author(s)
      Fujihara Y, Hikita A, Saijo H, Kanno Y, Takato T, Hoshi K
    • Organizer
      2015 4th TERMIS World Congress
    • Place of Presentation
      Boston, MA, USA, Boston Marriott Copley Place
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi