| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We regarded p53 gene known as tumor suppressor gene as "a guardian of the teratogenesis". It was intended to search effect of p53 on cleft lip and palate formation in the CL/Fr mouse (cleft lip and palate sensitive strain). We analyzed to use the p53 knockout CL/Fr mouse artificial insemination frozen embryos.
Cleft lip in the CL/Frp53(-/-) mouse was suggested to be caused by specific malformation without the report so far. The cleft palate in the p53(-/-) mouse was almost the clinical condition of so-called complete cleft palate, and the palatine process was found. The size of the palatine process was very small, and most of the growth to a horizontal direction was proved not to occur.
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