Elucidation of metastasis regulation mechanism of oral malignant melanoma by phosphodiesterase 1 inhibitor for novel therapeutic method

Research Project

Project/Area Number	15K11242
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Mie University
Principal Investigator	Shimizu Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
Co-Investigator(Kenkyū-buntansha)	村田琢三重大学, 医学部附属病院, 講師 (80242965)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	悪性腫瘍 / 悪性黒色腫 / Phosphodiesterase
Outline of Final Research Achievements	In this study, we elucidated the mechanism that PDE1 inhibitor suppresses mobility of malignant melanoma cells. Sildenafil inhibited the polymerization of actin at the leading edge of the human oral malignant melanoma MAA cells, and also inhibited the formation of lamellipodia. Since MAA cells express PDE1 and do not express PDE5, the elevation of intracellular cAMP concentration through inhibition of PDE1 may be involved in suppression of the mobility of MAA by sildenafil.

Report

(4 results)