Elucidation of metastasis regulation mechanism of oral malignant melanoma by phosphodiesterase 1 inhibitor for novel therapeutic method
| Project/Area Number |
15K11242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University |
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Principal Investigator |
Shimizu Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
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| Co-Investigator(Kenkyū-buntansha) |
村田 琢 三重大学, 医学部附属病院, 講師 (80242965)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 悪性腫瘍 / 悪性黒色腫 / Phosphodiesterase |
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| Outline of Final Research Achievements |
In this study, we elucidated the mechanism that PDE1 inhibitor suppresses mobility of malignant melanoma cells. Sildenafil inhibited the polymerization of actin at the leading edge of the human oral malignant melanoma MAA cells, and also inhibited the formation of lamellipodia. Since MAA cells express PDE1 and do not express PDE5, the elevation of intracellular cAMP concentration through inhibition of PDE1 may be involved in suppression of the mobility of MAA by sildenafil.
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Report
(4 results)
Research Products
(2 results)
