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Analyses of the effects of neuropeptides activated in hypothalamus on the characteristics of feeding behavior.

Research Project

Project/Area Number 15K11245
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

Tanaka Susumu  大阪大学, 歯学部附属病院, 講師 (00367541)

Co-Investigator(Kenkyū-buntansha) 古郷 幹彦  大阪大学, 歯学研究科, 教授 (20205371)
石濱 孝二  大阪大学, 歯学部附属病院, 招へい教員 (30432454)
榎本 明史  近畿大学, 医学部附属病院, 講師 (70432549)
辻 忠孝  大阪大学, 歯学部附属病院, 医員 (50527231)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳内生理活性物質 / 神経ペプチド / 顎口腔刺激 / 摂食行動 / 三叉神経中脳路核 / 三叉神経系
Outline of Final Research Achievements

We analyzed the effects of neuropeptides produced in the hypothalamic area on the pattern of feeding behavior using adult Wistar rats. Intraventricular injection of α-MSH, antiorexigenic agent, prolonged the latency to eat, decreased cumulative food intake and the duration of feeding bouts. In contrast, AgRP, orexigenic agent produced in arcuate nucleus, stimulated the drinking behavior in all cases examined, but showed only modest effects on the feeding behavior. We also examined the direct effects of neuropeptides on the membrane properties of mesencephalic trigeminal neurons using whole cell patch-clamp recording technique. Both orexin and NPY demonstrated inward current and stimulated membrane excitabilities by acceleration of spike repolarization and increase of spike frequency in repetitive discharges. These effects were suppressed in the presence of H89 or cherelythrine, suggesting the involvement of PKA, PKC dependent signaling pathway.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Development of resurgent and persistent sodium currents in mesencephalic trigeminal neurons.2018

    • Author(s)
      Akifumi Enomoto, Soju Seki, Susumu Tanaka, Kohji Ishihama, Tadashi Yamanishi, Mikihiko Kogo
    • Journal Title

      Journal of Neuroscience Research

      Volume: 96(2) Issue: 2 Pages: 305-312

    • DOI

      10.1002/jnr.24134

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Slow inward rectifying currents participates in control of bursting behavior in mesencephalic trigeminal neurons.2017

    • Author(s)
      Susumu Tanaka, Saori Yamada, Akifumi Enomoto, Soju Seki, Tadataka Tsuji, Mikihiko Kogo
    • Organizer
      Oral Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of resurgent and persistent sodium current in mesecephalic trigeminal neurons2017

    • Author(s)
      Akifumi Enomoto, Soju Seki, Susumu Tanaka, Kohji Ishihama, Tadashi Yamanishi, Mikihiko Kogo
    • Organizer
      Oral Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳内生理活性物質による三叉神経ニューロンの神経修飾作用に関わるシグナル伝達機構.2016

    • Author(s)
      67)山田早織,田中晋,関壮樹,小野雄大,辻忠孝,古郷幹彦.
    • Organizer
      第61回 日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県千葉市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Neuropeptide Y modulates the spike discharge characteristics in mesencephalic trigeminal neurons.2015

    • Author(s)
      Seki S, Tanaka S, Tsuji T, Ono Y, Kogo M
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Slow inward rectifying currents participate in control of bursting behavior in mesencephalic trigeminal neurons. in Oral Science in Japan 20162017

    • Author(s)
      Susumu Tanaka, Akifumi Enomoto, Saori Yamada, Soju Seki, Tadataka Tsuji, Kohji Ishihama, Mikihiko Kogo
    • Publisher
      Japanese Stomatological Society
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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