| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, we intended to develop a novel diagnostic and therapeutic method targeting cancer stem cells of human oral cancer and performed cellular and molecular biological characteristics analysis of CD133 positive cell group isolated from oral squamous cell carcinoma cell (OSCC) in serum - free culture system.
As a result, there was a transit mechanism from CD133 positive cells to negative cells or from CD133 negative cells to positive cells in OSCC. EGF and SHH were thought to promote transit from CD133 negative cells to positive cells. On the other hand, anticancer agent and hypoxic environment targeted only CD133 negative cells, and transit from negative cells to positive cells was considered not to be inhibited. It seems that the EGF and SHH pathways play an important role in maintaining the function of the positive cell OSCC.
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