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The role of ID protein family on proliferation and invasion of salivary gland cancer cells

Research Project

Project/Area Number 15K11257
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

SUMIDA TOMOKI  九州大学, 大学病院, 講師 (50314951)

Co-Investigator(Kenkyū-buntansha) 森 悦秀  九州大学, 歯学研究院, 教授 (00231639)
山田 朋弘  九州大学, 歯学研究院, 准教授 (60335619)
中野 旬之  九州大学, 大学病院, 講師 (60511730)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsID1 / ID2 / 唾液腺癌 / 浸潤、転移 / Id2 / 扁平上皮癌 / 唾液腺腫瘍 / ホルモン療法 / IDタンパク / 性ステロイドホルモン / ID遺伝子ファミリー
Outline of Final Research Achievements

Inhibitors of DNA-binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. We previously determined that ID1 was highly expressed in aggressive salivary gland cancer (SGC) cells in culture. Here, we show that ID2 is also expressed in aggressive SGC cells. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. Moreover, ID2 knockdown almost completely suppresses invasion and the expression of matrix metalloproteinase 9. In conclusion, ID2 expression maintains an aggressive phenotype in SGC cells, and ID2 repression triggers a reduction in cell aggressiveness.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (1 results)

  • [Int'l Joint Research] 1. California Pacific Medical Center/Research Institute(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2015 Research-status Report
  • [Journal Article] Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.2018

    • Author(s)
      Ishibashi K, Ishii K, Sugiyama G, Sumida T, Sugiura T, Kamata YU, Seki K, Fujinaga T, Kumamaru W, Kobayashi Y, Hiyake N, Nakano H, Yamada T, Mori Y.
    • Journal Title

      Anticancer Res.

      Volume: 38 Pages: 187-197

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma.2018

    • Author(s)
      Ishibashi K, Ishii K, Sugiyama G, Kamata YU, Suzuki A, Kumamaru W, Ohyama Y, Nakano H, Kiyoshima T, Sumida T, Yamada T, Mori Y.
    • Journal Title

      Cancer Genomics Proteomics.

      Volume: 15 Pages: 53-60

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estrogen Enhances Malignant Phenotypes in Human Salivary Adenoid Cystic Carcinoma Cells.2016

    • Author(s)
      Sumida T, Ishikawa A, Kamata YU, et al.
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 2793-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression2016

    • Author(s)
      Ryuichi Murase, Tomoki Sumida, Rumi Kawamura, Akiko Onishi-Ishikawa, Hiroyuki Hamakawa, Sean D. McAllister, Pierre-Yves Desprez.
    • Journal Title

      Cancer letters

      Volume: 16 Issue: 1 Pages: 11-16

    • DOI

      10.1016/j.canlet.2016.04.021

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Id2が口腔扁平上皮癌細胞の増殖・浸潤に及ぼす影響2017

    • Author(s)
      鎌田 裕・住田知樹・石橋佳奈・小林洋輔・熊丸 渉・石井広太郎・中野旬之・山田朋弘・森 悦秀
    • Organizer
      第62回(公社)日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2022-01-24  

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