| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
It was revealed that the cytoreduction of mouse explanted tumors were affected by cancer gene therapy with E3C1. Additionally, its effect of cytoreduction was histological change of tumor vessel in 2015. It was revealed that the gene therapy with E3C1 effected on pericyte and Tip cell of perivascular cells in 2016. It was revealed that tumor vessel fail to function. Because, the pericyte of tumor perivascular cells were effected by the gene therapy with E3C1 2017.
As above, the gene therapy with E3C1 effected the pericyte of tumor perivascular cells. Accordingly, vascular endothelial cells can not maintain for vascular lumen. Therefore, it was suggested that the effusion emigrated of intravascular.
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