| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this research project is to analyze the effect on prevention / progression of oral mucositis accompanying cancer chemotherapy by antioxidant pretreatment. Alphal-glucosyl-hesperidin which is a water-soluble antioxidant substance and Chinese herbal medicine which is indicated for efficacy to oral mucositis, Hange-shashin-to/Inchinko-to/Oren-to indicated the satisfactory reactive oxygen species scavenging activity. In addition, exacerbation of oral mucositis was significantly suppressed by administering these antioxidants in vivo to experimental animals before prescribing chemotherapy. However, although the maximum area of oral mucositis caused as compared with the control was suppressed, shortening of the recovery period was not observed. From now on, it is necessary to combine with lipid-soluble antioxidants and others to aim for recovery of treatment period.
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