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Investigation of new treatment management to try to prevent progression and exacerbation of oral mucositis

Research Project

Project/Area Number 15K11275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

Fumihiko Yoshino  神奈川歯科大学, 大学院歯学研究科, 准教授 (20308307)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口内炎 / 活性酸素 / 漢方薬 / 化学療法 / 茵蔯蒿湯 / 半夏瀉心湯 / 黄連湯 / 抗酸化作用 / 抗酸化物質 / ファイトケミカル / 抗癌剤
Outline of Final Research Achievements

The aim of this research project is to analyze the effect on prevention / progression of oral mucositis accompanying cancer chemotherapy by antioxidant pretreatment. Alphal-glucosyl-hesperidin which is a water-soluble antioxidant substance and Chinese herbal medicine which is indicated for efficacy to oral mucositis, Hange-shashin-to/Inchinko-to/Oren-to indicated the satisfactory reactive oxygen species scavenging activity. In addition, exacerbation of oral mucositis was significantly suppressed by administering these antioxidants in vivo to experimental animals before prescribing chemotherapy. However, although the maximum area of oral mucositis caused as compared with the control was suppressed, shortening of the recovery period was not observed. From now on, it is necessary to combine with lipid-soluble antioxidants and others to aim for recovery of treatment period.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Journal Article (8 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 8 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Bactericidal effect of hydroxyl radicals generated by the sonolysis and photolysis of hydrogen peroxide for endodontic applications2017

    • Author(s)
      Ibi H, Hayashi M, Yoshino F, Tamura M, Yoshida A, Kobayashi Y, Shimizu K, Lee M-C, Imai K, Ogiso B
    • Journal Title

      Microbial Pathogenesis

      Volume: 103 Pages: 65-70

    • DOI

      10.1016/j.micpath.2016.12.010

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antimicrobial effect of blue light using Porphyromonas gingivalis pigment2017

    • Author(s)
      Yoshida Ayaka、Sasaki Haruka、Toyama Toshizo、Araki Mitsunori、Fujioka Jun、Tsukiyama Koichi、Hamada Nobushiro、Yoshino Fumihiko
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 5225-5225

    • DOI

      10.1038/s41598-017-05706-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antimicrobial effect of titanium dioxide after ultraviolet irradiation against periodontal pathogen2016

    • Author(s)
      Shirai R, Miura T, Yoshida A, Yoshino F, Ito T, Yoshinari M, Yajima Y
    • Journal Title

      Dental Materials Journal

      Volume: 35 Issue: 3 Pages: 511-516

    • DOI

      10.4012/dmj.2015-406

    • NAID

      130005155189

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Porphyromonas gingivalis infection modifies oral microcirculation and aortic vascular function in the stroke-prone spontaneously hypertensive rat (SHRSP).2016

    • Author(s)
      Funaki S, Tokutomi F, Wada-Takahashi S, Yoshino F, Yoshida A, Maehata Y, Miyamoto C, Toyama T, Sato T, Hamada N, Lee M-C, Takahashi S-S
    • Journal Title

      Microbial Pathogenesis

      Volume: 92 Pages: 36-42

    • DOI

      10.1016/j.micpath.2015.12.009

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] α-glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch.2016

    • Author(s)
      Yoshino F, Yoshida A, Toyama T, Wada-Takahashi S, Takahashi S-S
    • Journal Title

      Journal of Functional Foods

      Volume: 21 Pages: 223-231

    • DOI

      10.1016/j.jff.2015.12.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Protective effects of (6R)-5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva2016

    • Author(s)
      Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi S-S, Watanabe K, Lee M-C, Todoki K, Hamada N
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 1 Pages: 69-75

    • DOI

      10.3164/jcbn.15-69

    • NAID

      130005116629

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blue light irradiation-induced oxidative stress in vivo via ROS generation in rat gingival tissue.2015

    • Author(s)
      Yoshida A, Shiotsu-Ogura Y, Wada-Takahashi S, Takahashi S-S, Toyama T, Yoshino F
    • Journal Title

      Journal of Photochemistry and Photobiology B: Biology

      Volume: 151 Pages: 48-53

    • DOI

      10.1016/j.jphotobiol.2015.07.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship among salivary antioxidant activity, cytokines and periodontitis: the Nagasaki Island study.2015

    • Author(s)
      Tamaki N, Yoshino F, Fukui M, Hayashida H, Yoshida A, Kitamura M, Iwasaki T, Furugen R, Kawasaki K, Nakazato M, Maeda T, Kokeguchi S, Yamamoto T, Lee M-C, Ito H, Saito T
    • Journal Title

      Journal of Clinical Periodontology

      Volume: 42 Issue: 8 Pages: 711-718

    • DOI

      10.1111/jcpe.12438

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] The Effect of α-glucosyl Hesperidin on Oral Mucositis Induced by Treatment of 5-fluorouracil with Acetic Acid.2017

    • Author(s)
      Yoshino F, Yoshida A,Toyama T
    • Organizer
      CED-IADR/NOF Oral Health Research Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The inhibition mechanism of gingival fibroblast proliferation by blue-light irradiation.2017

    • Author(s)
      Yoshida A, Yoshino F
    • Organizer
      CED-IADR/NOF Oral Health Research Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス実験的歯周病炎モデルにおける生薬「鶏血藤」の循環改善効果2017

    • Author(s)
      遠山歳三,塗々木和男,高橋俊介,吉野文彦,吉田彩佳,松尾雅斗,高橋聡子,佐々木 悠,稲葉啓太郎,渡辺清子,浜田信城
    • Organizer
      日本歯周病学会 60 周年記念京都大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Antibacterial Activity of Infrared Free Electron Laser on Cariogenic Bacteria2017

    • Author(s)
      oyama T, Fujioka J, Koyata Y, Sakuma T, Watanabe K, Sasaki H, Yoshino F, Yoshida A, Tsukiyama K, Hamada N
    • Organizer
      95th General session & Exhibition of the IADR, 46th Annual meeting of the AADR and 41th Annual meeting of the CADR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study of Blue-light Effect on rat palatal gingiva.2016

    • Author(s)
      Yoshida A, Yoshino F
    • Organizer
      45th Annual meeting of the AADR
    • Place of Presentation
      Los Angeles, CA, USA.
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖転移ヘスペリジンの難治性口内炎に対する増悪改善効果.2016

    • Author(s)
      吉野文彦
    • Organizer
      糖転移ヘスペリジン・ビタミンP研究会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ガン化学療法に併発する口内炎に対する糖転移ヘスペリジンの効果2016

    • Author(s)
      吉野文彦,吉田彩佳,小椋有香子,遠山歳三,高橋聡子,高橋俊介
    • Organizer
      神奈川歯科大学学会 第 51 回総会
    • Place of Presentation
      神奈川県横須賀市
    • Related Report
      2016 Research-status Report
  • [Remarks] 神奈川歯科大学大学院口腔科学講座光歯科医学

    • URL

      http://www.labs.kdu.ac.jp/pmd/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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