Research Project
Grant-in-Aid for Scientific Research (C)
Were histopathological, and analyzed the DNA which we obtained from an oral squamous cell carcinoma tissue of regional node-positive case pN(+) and negative case pN(-) by Mapping Array, and detected genome copy number abnormality to be common to a pN(+) case as compared with a pN(-) case, and to be found, and listed candidate metastasis-related gene which was present in theatrical company rank. As a result of Real-time PCR, an expression of Sirt1 mRNA decrease was found in 47.1% of oral squamous cell carcinoma tissue as compared with a normal oral tissue of the resection stump neighborhood.Sirt1 had the tendency indicating the expression decrease in a pN(+) case frequently.The likelihood that Sirt1 played an important role in in progress and lymph node metastases of oral squamous cell carcinoma was suggested.
All 2018 2017 2016 2015
All Journal Article (6 results) (of which Peer Reviewed: 6 results, Open Access: 5 results, Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Invited: 1 results) Book (3 results)
The Bulletin Tokyo Dental College
Volume: in press
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 28 Pages: 26-29
Japanese Dental Science Review
Volume: 51 Pages: 25-33
50009645831
Kanagawa Shigaku
Volume: 50 Pages: 73-81
Volume: 27 Pages: 92-95
Japanese Journal of Oral Diagnosis/Oral Medicine
Volume: 28 Pages: 147-152
