Promotion of cell proliferation by the proto-oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization
Project/Area Number |
15K11289
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Gifu University |
Principal Investigator |
TOMITA HIROYUKI 岐阜大学, 大学院医学系研究科, 准教授 (50509510)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 口腔癌 / DEK / 扁平上皮癌 / 癌 / 口腔 |
Outline of Final Research Achievements |
Oral squamous cell carcinoma (OSCC) develops through a multistep carcinogenic process involving field cancerization. DEK overexpression is associated with malignancies; however, the functional roles of DEK overexpression are unclear. We demonstrated that DEK-expressing cells were significantly increased in human dysplasia/carcinoma in situ and OSCC. Furthermore, we generated ubiquitous and squamous cell-specific doxycycline (DOX)-inducible Dek mice (iDek and iDek-e mice respectively). Both DOX+ iDek and iDek-e mice did not show differences in the oral mucosa compared with DOX- mice. In the environment exposed to carcinogen, DOX-treated (DOX+) iDek mice showed field cancerization and OSCC development. Microarray analysis revealed that DEK overexpression was mediated by the upregulation of DNA replication- and cell cycle-related genes, particularly those related to the G1 /S transition. T
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Report
(4 results)
Research Products
(1 results)
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[Journal Article] Promotion of cell proliferation by the proto-oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization2017
Author(s)
Nakashima, T. Tomita, H. Hirata, A. Ishida, K. Hisamatsu, K. Hatano, Y. Kanayama, T. Niwa, A. Noguchi, K. Kato, K. Miyazaki, T. Tanaka, T. Shibata, T. Hara, A.
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Journal Title
Cancer Med
Volume: 6
Issue: 10
Pages: 2424-2439
DOI
Related Report
Peer Reviewed / Open Access