Study on the mechanisms of acquiring cancer stem cell-like characteristics related with HPV-16 E6 gene in oral squamous cell carcinomas
Project/Area Number |
15K11290
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
Sugiyama Masaru 広島大学, 医系科学研究科(歯), 教授 (70187681)
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Co-Investigator(Kenkyū-buntansha) |
重石 英生 広島大学, 医歯薬保健学研究科(歯), 講師 (90397943)
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | HPV / リスクファクター / 口腔癌 / HPV16 / 癌幹細胞 / 口腔 / 中咽頭 |
Outline of Final Research Achievements |
Oral rinse and gargle samples obtained from 94 healthy individuals were tested for HPV16 DNA by PCR. The percentage of HPV16-positive cases was higher in the gargle (28.7%) as compared to the oral rinse (16.0%) samples. In the oral rinse samples, males showed a significantly higher rate of HPV16 than females.To identify the risk factors for oral HPV infection, we performed systematic review and meta-analysis of studies reporting the prevalence of oral HPV infection in healthy individuals. Sexual behavior and smoking were importantly related to oral HPV infection in healthy individuals.
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Academic Significance and Societal Importance of the Research Achievements |
咽頭含嗽サンプルが口腔含嗽サンプルよりもHPV16 DNA陽性率が高い理由として,中咽頭の組織学的特徴の関与が考えられた.また,口腔内の衛生環境とHPV感染には密接な関連があり,口腔衛生状態を良好に保つことは,口腔のHPV感染を予防するために重要であると考えられる. HPV関連口腔癌の予防を科学的根拠に基づいて行うために,HPV DNA陽性口腔癌におけるHPVの役割を明確にする必要があり,口腔HPV感染の基礎および臨床的研究の推進が望まれる.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3β-dependent cancer stem cell properties.2016
Author(s)
Seino S, Shigeishi H, Hashikata M, Higashikawa K, Tobiume K, Uetsuki R, Ishida Y, Sasaki K, Naruse T, Rahman MZ, Ono S, Simasue H, Ohta K, Sugiyama M, Takechi M.
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Journal Title
J Oral Pathol Med
Volume: 45
Issue: 3
Pages: 180-188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological analysis of salivary gland carcinomas and literature review.2015
Author(s)
Shigeishi H, Ohta K, Okui G, Seino S, Hashikata M, Yamamoto K, Ishida Y, Sasaki K, Naruse T, Rahman MZ, Uetsuki R, Nimiya A, Ono S, Shimasue H, Higashikawa K, Sugiyama M, Takechi M.
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Journal Title
Mol Clin Oncol.
Volume: 3
Pages: 202-206
Related Report
Peer Reviewed / Open Access
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