Development of new oral cancer treatments focused on mTOR inhibition leading to the anti-aging prevention and the healthy life-span extension
Project/Area Number |
15K11292
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Yamaguchi University |
Principal Investigator |
HARADA Koji 山口大学, 大学院医学系研究科, 助教 (60253217)
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Research Collaborator |
FERDOUS Tarannum
MINAMI Haruyasu
FUJIWARA Rieko
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | mTOR阻害剤 / ラパマイシン / 5-FU / 老化防止 / 健康寿命延長 / 口腔癌 / 口腔扁平上皮癌 / Rapamycin / 5-FU / 併用療法 / リンパ管新生抑制 / 細胞老化抑制 / mTOR阻害 / アポトーシス / 健康寿命 |
Outline of Final Research Achievements |
We investigated the combined effect one of mTOR inhibitors (rapamycin, everolimus or temsirolimus) and any of conventional anticancer agents (5-FU, CDDP, DOC, PTX, C-mab or radiation). Rapamycin in combination with 5-FU exerted maximum growth inhibitory effects on OSCC cell lines and nude mice tumors. Immunohistochemical staining showed that the expressions of p16, VEGF and podoplanin were down-regulated, and the expressions of PI3K, Akt , p27, and p21 were up-regulated on nude mice tumors treated with rapamycin and 5-FU. These findings suggested that the combined therapy of rapamycin and 5-FU might be an new oral cancer treatments focused on mTOR inhibition leading to the anti-aging prevention and the healthy life-span extension.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Efficacy of elemental diet on prevention for chemoradiotherapy-induced oral mucositis in patients with oral squamous cell carcinoma2016
Author(s)
Koji Harada, Tarannum Ferdous, Daiju Horinaga, Kenichiro Uchida, Takamitsu Mano, Katsuaki Mishima, SungChul Park, Hideki Hanazawa, Shotaro Takahashi, Atsumi Okita, Misaki Fukunaga, Junko Maruta, Naoko Kami, Keiko Shibuya, Yoshiya Ueyama
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Journal Title
Support Care Cancer
Volume: 24
Issue: 2
Pages: 953-959
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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