microRNA which promotes the diseminated tumor cell which participates in distant metastasis of the oral cancer

• Project/Area Number: 15K11295
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YANAMOTO Souichi 長崎大学, 病院(歯学系), 講師 (10315260)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 播種性腫瘍細胞 / 口腔癌 / microRNA / 高播種性腫瘍細胞 / 高浸潤 / 遠隔転移

Outline of Final Research Achievements

The aim of this study was to verify whether microRNA participates for the object and making more disseminated tumor cell (DTC) a treatment mark. It's high seeding as an outcome, a tumor cell could do a thing with remote metastaticity clearly, and a possibility that miR-21 participates in the formative process was suggested. DKK2 was considered as a strong molecule as a mark molecule of miR-21. More DKK2 and manifestation of intercellular adhesion molecule were obstructed by miR-21 significantly, and a possibility that this mechanism participates in the special quality of DTC closely was suggested.

Research Products

• [Journal Article] Multicenter retrospective study of cetuximab plus platinum-based chemotherapy for recurrent or metastatic oral squamous cell carcinoma (2018)
  • Author(s): Yanamoto Souichi、Umeda Masahiro、Kioi Mitomu、Kirita Tadaaki、Yamashita Tetsuro、Hiratsuka Hiroyoshi、Yokoo Satoshi、Tanzawa Hideki、Uzawa Narikazu、Shibahara Takahiko、Ota Yoshihide、Kurita Hiroshi、Okura Masaya、Hamakawa Hiroyuki、Kusukawa Jingo、Tohnai Iwai
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 81 Issue: 3 Pages: 549-554
  • DOI: 10.1007/s00280-018-3531-x
  • Peer Reviewed / Open Access
• [Journal Article] Progression level of extracapsular spread and tumor budding for cervical lymph node metastasis of OSCC (2017)
  • Author(s): Yamada Shin-ichi、Otsuru Mitsunobu、Yanamoto Souichi、Hasegawa Takumi、Aizawa Hitoshi、Kamata Takahiro、Yamakawa Nobuhiro、Kohgo Tomoyuki、Ito Akira、Noda Yuri、Hirai Chihoko、Kitamura Tetsuya、Okura Masaya、
  • Journal Title: Clinical Oral Investigations Volume: 22 Issue: 3 Pages: 1311-1318
  • DOI: 10.1007/s00784-017-2231-y
  • Peer Reviewed / Open Access
• [Journal Article] Natriuretic peptide receptor A is related to the expression of vascular endothelial growth factors A and C, and is associated with the invasion potential of tongue squamous cell carcinoma (2017)
  • Author(s): Nakao Y.、Yamada S.、Yanamoto S.、Tomioka T.、Naruse T.、Ikeda T.、Kurita H.、Umeda M.
  • Journal Title: International Journal of Oral and Maxillofacial Surgery Volume: 46 Issue: 10 Pages: 1237-1242
  • DOI: 10.1016/j.ijom.2017.04.022
  • Peer Reviewed
• [Journal Article] Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence (2017)
  • Author(s): Hasegawa Takumi、Yanamoto Souichi、Otsuru Mitsunobu、Yamada Shin-ichi、Minamikawa Tsutomu、Shigeta Takashi、Naruse Tomofumi、Suzuki Takatsugu、Sasaki Masashi、Ota Yoshihide、Umeda Masahiro、Komori Takahide
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Volume: 123 Issue: 5 Pages: 524-530
  • DOI: 10.1016/j.oooo.2016.11.014
  • Peer Reviewed
• [Journal Article] Therapeutic implication of mTORC2 in oral squamous cell carcinoma. (2017)
  • Author(s): Naruse T, Yanamoto S, Okuyama K, Yamashita K, Omori K, Nakao Y, Yamada SI, Umeda M.
  • Journal Title: Oral Oncol Volume: 65 Pages: 23-32
  • DOI: 10.1016/j.oraloncology.2016.12.012
  • Peer Reviewed