| Project/Area Number |
15K11297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
Hamada Tomofumi 鹿児島大学, 医歯学域附属病院, 講師 (00444894)
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| Co-Investigator(Kenkyū-buntansha) |
横山 勢也 鹿児島大学, 医歯学域医学系, 助教 (20569941)
杉浦 剛 鹿児島大学, 医歯学域歯学系, 教授 (40322292)
河野 憲司 大分大学, 医学部, 教授 (50214664)
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| Co-Investigator(Renkei-kenkyūsha) |
Yamada Norisige 京都大学, 医学研究科, 研究員 (60625242)
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| Research Collaborator |
NAKAMURA Kodai 鹿児島大学, 附属病院, 医員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔癌 / がん検診 / DNAメチル化 / エピゲノム / 前癌病変 / うがい液 / 口腔扁平上皮癌 / 癌抑制遺伝子 / 早期発見 |
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| Outline of Final Research Achievements |
The purpose of this study is to find oral precancerous lesion-specific aberrant DNA methylation, and to establish the screening tool for the early detection of oral cancer/precancer. Gargle fluid samples were obteined from patients with leukoplakia and healthy subjects. Using selected cancer-related genes, the sensitivity and specify for oral precancer detection is 98% and 94, respectively. This novel method using aberrant DNA methylation might be useful for noninvasive screening for the patients with oral cancer/precancer.
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