Noninvasive detection of oral cancer and precancerous lesion using aberrant DNA methylation in gargle fluid samples
Project/Area Number |
15K11297
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kagoshima University |
Principal Investigator |
Hamada Tomofumi 鹿児島大学, 医歯学域附属病院, 講師 (00444894)
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Co-Investigator(Kenkyū-buntansha) |
横山 勢也 鹿児島大学, 医歯学域医学系, 助教 (20569941)
杉浦 剛 鹿児島大学, 医歯学域歯学系, 教授 (40322292)
河野 憲司 大分大学, 医学部, 教授 (50214664)
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Co-Investigator(Renkei-kenkyūsha) |
Yamada Norisige 京都大学, 医学研究科, 研究員 (60625242)
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Research Collaborator |
NAKAMURA Kodai 鹿児島大学, 附属病院, 医員
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 口腔癌 / がん検診 / DNAメチル化 / エピゲノム / 前癌病変 / うがい液 / 口腔扁平上皮癌 / 癌抑制遺伝子 / 早期発見 |
Outline of Final Research Achievements |
The purpose of this study is to find oral precancerous lesion-specific aberrant DNA methylation, and to establish the screening tool for the early detection of oral cancer/precancer. Gargle fluid samples were obteined from patients with leukoplakia and healthy subjects. Using selected cancer-related genes, the sensitivity and specify for oral precancer detection is 98% and 94, respectively. This novel method using aberrant DNA methylation might be useful for noninvasive screening for the patients with oral cancer/precancer.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer2017
Author(s)
Yokoyama, S. Higashi, M. Tsutsumida, H. Wakimoto, J. Hamada, T. Wiest, E. Matsuo, K. Kitazono, I. Goto, Y. Guo, X. Hamada, T. Yamada, S. Hiraki, T. Yonezawa, S. Batra, S. K. Hollingsworth, M. A. Tanimoto, A.
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Journal Title
Genes & cancer
Volume: 8
Issue: 3-4
Pages: 517-527
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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