| Project/Area Number |
15K11301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
近藤 誠二 昭和大学, 歯学部, 准教授 (10432634)
代田 達夫 昭和大学, 歯学部, 教授 (60235760)
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| Research Collaborator |
KATO Kosuke 昭和大学, 歯学部
ITO Chihiro 昭和大学, 歯学部
MOTOHASHI Hiromi 昭和大学, 歯学部
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | TPD52ファミリー / TPD54 / 口腔癌 / 扁平上皮癌 / TPD52 / TPD52 family / Cancer / Squamous Cell Cartinoma |
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| Outline of Final Research Achievements |
In the present study, we investigated the epigenetic post-translational regulation system of gene expression of TPD54, a member of TPD52 protein family. As well, we identified a novel intra-cellular protein, which binds to TPD54. These findings suggest a novel role of TPD54 protein as a molecular target for cancer theraputics. As a result, it was revealed that TPD54 regulates the secration of a certain secration protein, which is involved in proliferation and invasion of aquamous cell cartinoma (OSCC) cells, by the intra-cellular interaction; thereby it is suggested that this interaction might regulate the ability of proliferation and invasion of OSCC cells.
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