Development of a next generation type reconstruction method using biogradable magnesium alloy mesh
| Project/Area Number |
15K11305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山内 健介 東北大学, 歯学研究科, 准教授 (10364150)
清水 良央 東北大学, 歯学研究科, 助教 (30302152)
向井 敏司 神戸大学, 工学研究科, 教授 (40254429)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生分解性 / マグネシウム合金 / 生体遺残 / 材料学的強度 / 顎骨再建 / 骨移植 / ピン / 細胞毒性 / 生体安全性 / 水素 / メッシュ / 機械的特性 / 分解特性試験 |
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| Outline of Final Research Achievements |
To solve the problems concerning residues in the body and strength of the biomaterials, we performed a research of a next generation reconstruction method using biogradable magnesium alloy mesh and got the next results. 1. The living body safety was confirmed by in vitro cell toxicological test of a containing element and in vivo rat back subcutaneous transplantation. But the hydrogen gassing was confirmed by the absorption process. 2. Development of a bone transplantation fixed way by a biodegradablility magnesium alloy pin: A magnesium alloy pin of transplantation bone fixing (Mg pin) has been developed. It was possible to fix a bone fragment for 24 weeks by a Mg pin by an experiment of rabbit.No complications were observed in a follow up period for 6 months postoeprtively, and the healing process was excellent. Control of hydrogen gas which occurs in an absorption early stage of a Mg pin and consideration of surface design of the Mg pin seemed to be necessary.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] A Strategy against the Osteonecrosis of the Jaw Associated with Nitrogen-Containing Bisphosphonates (N-BPs): Attempts to Replace N-BPs with the Non-N-BP Etidronate2016
Author(s)
Oizumi T, Yamaguchi K, Sato K, Okada S, Suzuki H, Funayama H, Mori S, Nagasaka H, Tsuchiya M, Hagiwara W, Itoi E, Sugawara S, Takahashi T, Endo Y:
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 39
Issue: 9
Pages: 1549-1554
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical evaluations of autologous fibrin glue and polyglycolic acid sheets as oral surgical wound coverings after partial glossectomy.2016
Author(s)
Kouketsu A, Nogami S, Fujiwara M, Mori S, Yamauchi K, Hashimoto W, Miyashita H, Kurihara J, Kawai T, Higuchi K, Takahashi T.
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Journal Title
Journal of Craniomaxillofacial Surgery
Volume: 44
Issue: 8
Pages: 964-968
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Reconstruction of a dog mandibular resection defect by octacalcium phosphate collagen composite.2015
Author(s)
Kawai T, Matsui K, Ezoe Y, Tanuma Y, Tanaka H, Kajii F, Iwai A, Takahashi T, Suzuki O, Kamakura S.
Organizer
27rd European Conference on Biomaterials
Place of Presentation
Krakow, POLAND
Year and Date
2015-08-30
Related Report
Int'l Joint Research
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