Acceleration of differentiation and maturation of iPS cell via coculture with matuer cells
Project/Area Number |
15K11306
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | The University of Tokyo |
Principal Investigator |
Saijo Hideto 東京大学, 医学部附属病院, 准教授 (80372390)
|
Co-Investigator(Kenkyū-buntansha) |
星 和人 東京大学, 医学部附属病院, 教授 (30344451)
杉山 円 東京大学, 医学部附属病院, 助教 (90451814)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | iPS細胞 / 成熟細胞 / 共培養 |
Outline of Final Research Achievements |
There are so many risks of bone defect in oral and maxillofacial region that realization of bone regenerative therapy such as utilization of iPS cells is being waited. We considered that the efficient protocol to differentiate iPS cells into mature cells is to place iPS cells in vivo and have iPS cells to receive maturation promoting factors from surrounding mature cells. In this research, we examined murine iPS cells, human mature mesodermal cells, and human iPS cells by coculture with pellets mimicking in vivo environment, and in vivo transplantation of cells originate from iPS cells. We developed a safe and efficient protocol to differentiate iPS cells into regenerative bone tissue.
|
Report
(4 results)
Research Products
(8 results)
-
-
-
[Journal Article] <b>Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem </b><b>cells </b>2015
Author(s)
Saito T, Yano F, Mori D, Kawata M, Hoshi K, Takato T, Masaki H, Otsu M, Eto K, Nakauchi H, Chung UI, Tanaka S
-
Journal Title
Biomedical Research
Volume: 36
Issue: 3
Pages: 179-186
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access
-
-
-
-
-