Evaluation of perioperative obstructive sleep apnea in patient with dentofacial deformity

• Project/Area Number: 15K11310
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kanazawa University
• Principal Investigator: OOI Kazuhiro 金沢大学, 附属病院, 講師 (90451450)
• Co-Investigator(Kenkyū-buntansha): 中村 博幸 金沢大学, 医学系, 准教授 (30542253)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 顎変形症 / 気道通気状態 / 睡眠呼吸障害 / ポリソムノグラフィー / 周術期管理 / 睡眠時咬筋活動 / 気道 / 顎矯正手術 / 上気道通気状態 / CT / PSG

Outline of Final Research Achievements

Polysomnography was performed before orthographic surgery and sleep state were measured using peripheral arterial tonometry over night during 7 nights after surgery in general anesthesia. Apnea hypopnea index (AHI), lowest arterial oxgen saturation (LoSpO2) and sleep state were measured. AHI: 0.4 ( 0-12.1) /h, LoSpO2 : 92 (85-95)％, REM 20.1 (0-34.1)％, NREM 79.9 (65.9-100 ) ％,.One patient was diagnosed mild OSA. AHI during REM 1.8 (0-21) was higher than AHI during NREM 0.2 (0-9.7). The perioperative REM sleep was low until the 3 days after surgery and increased on the 4 days after surgery. pAHI increased from 3days after surgery, the highest in 4 cases on 7days after surgery, SPO 2 was the lowest in 3 cases on 4days after surgery and 5 peoples on 7days after surgery. The perioperative pAHI ( 9.2 (2.7-26.3)) is increase according to high BMI and high preoperative AHI. The perioperative lower SPO 2 (87.7 (74 - 94)) is decrease according to less upward movement of mandibular incisor.

Research Products

• [Int'l Joint Research] University of Liverpool(英国)
• [Int'l Joint Research] Stanford University(米国)
• [Int'l Joint Research] スタンフォード大学(米国)
• [Int'l Joint Research] リバプール大学(英国)
• [Presentation] EVALUATION OF OBSTRUCTIVE SLEEP APNEA AND SLEEP QUALITY IN PATIENTS WITH SKELETAL CLASS Ⅲ MALOCCLUSION (2017)
  • Author(s): K. Ooi, R. Jokaji, K. Ide, Y. Kobayashi, N. Noguchi, K. Katoh, H. Nakamura, S. Takamichi, M. Nakata, K. Kasahara, S. Kawashiri
  • Organizer: International conference for oral and maxillofacial surgery 2017
  • Place of Presentation: 香港
  • Year and Date: 2017-03-31
  • Int'l Joint Research
• [Presentation] PERIOPERATIVE EVALUATION AND MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA AFTER MANDIBULAR SETBACK BY SAGGITAL SPLITTING RAMUS OSTEOTOMY (2017)
  • Author(s): R. Jokaji, K. Ooi, K. Ide, M. Ishimiya, Y. Kobayashi, H. Kitahara, N. Noguchi, K. Katoh, H. Nakamura, S. Takamichi, M. Nakata, K. Kasahara, S. Kawashiri
  • Organizer: International conference for oral and maxillofacial surgery 2017
  • Place of Presentation: 香港
  • Year and Date: 2017-03-31
  • Int'l Joint Research
• [Presentation] EVALUATION OF OBSTRUCTIVE SLEEP APNEAUSING PERIPHERAL ARTERIAL TONOMETRY DURING PERIOPERATIVE PERIOD AFTER REMOVAL OF IMPACTED THIRD MOLAR WITH DENTOFACIAL DEFOTMITY IN GENERAL ANETHESIA (2017)
  • Author(s): Y. Kobayashi, K. Ooi, R. Jyokaji, N. Noguchi, K. Katoh, H. Nakamura, S. Takamichi, N. Nakata, T. Kasahara, S. Kawashiri
  • Organizer: International conference for oral and maxillofacial surgery 2017
  • Place of Presentation: 香港
  • Year and Date: 2017-03-31
  • Int'l Joint Research
• [Presentation] EVALUATION OF OBSTRUCTIVE SLEEP APNEA AND SLEEP QUALITY IN PATIENTS WITH SKELETAL CLASS Ⅲ MALOCCLUSION (2017)
  • Author(s): K. Ooi, R. Jokaji, K. Ide, Y. Kobayashi, N. Noguchi, K. Katoh, H. Nakamura, S. Takamichi, M. Nakata, K. Kasahara, S. Kawashiri
  • Organizer: International Conference on Oral and Maxillofacial Surgery 2017
  • Int'l Joint Research
• [Presentation] PERIOPERATIVE EVALUATION AND MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA AFTER MANDIBULAR SETBACK BY SAGGITAL SPLITTING RAMUS OSTEOTOMY (2017)
  • Author(s): R. Jokaji, K. Ooi, K. Ide, M. Ishimiya, Y. Kobayashi, H. Kitahara, N. Noguchi, K. Katoh, H. Nakamura, S. Takamichi, M. Nakata, K. Kasahara, S. Kawashiri
  • Organizer: International Conference of Oral and Maxillofacial Surgery 2017
  • Int'l Joint Research
• [Presentation] EVALUATION OF OBSTRUCTIVE SLEEP APNEA USING PERIPHERAL ARTERIAL TONOMETRY DURING PERIOPERATIVE PERIOD AFTER REMOVAL OF IMPACTED THIRD MOLAR WITH DENTOFACIAL DEFOTMITY IN GENERAL ANETHESIA (2017)
  • Author(s): Y. Kobayashi, K. Ooi, K. Ide, R. Jokaji, N. Noguchi, K. Katoh, H. Nakamura, S. Takamichi, M. Nakata, K. Kasahara, S. Kawashiri,
  • Organizer: International Conference of Oral and Maxillofacial Surgery 2017
  • Int'l Joint Research
• [Presentation] 下顎前突症患者における周術期の閉塞性睡眠呼吸障害の評価とその予測因子 (2017)
  • Author(s): 大井一浩，定梶嶺，井手健太郎，大矢明日香，小林泰，野口夏代，加藤広禄，中村博幸，川尻秀一
  • Organizer: 日本口腔外科学会総会
• [Presentation] 簡易型睡眠評価装置を用いた顎矯正手術の周術期における睡眠呼吸状態の評価 (2017)
  • Author(s): 井手 健太郎，大井 一浩，麩谷 圭昭，小林 泰，定梶 嶺
  • Organizer: 日本睡眠歯科学会総会
• [Presentation] 全身麻酔下で埋伏智歯抜歯術を行った骨格性顎変形症患者の術前後における睡眠相の変化 (2017)
  • Author(s): 小林泰、 大井一浩, 麸谷 圭昭, 井手 健太郎2, 定梶 嶺
  • Organizer: 日本睡眠歯科学会総会