| Project/Area Number |
15K11311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
Makita Hiroki 岐阜大学, 大学院医学系研究科, 講師 (50345790)
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| Co-Investigator(Kenkyū-buntansha) |
柴田 敏之 岐阜大学, 大学院医学系研究科, 教授 (50226172)
米本 和弘 岐阜大学, 医学部附属病院, 助教 (80422731)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔癌 / 早期癌 / 分子イメージング / グルコーストランスポーター１ / ラット舌癌モデル / バイオマーカー / 舌癌 / 前癌病変 / グルコーストランスポーター / 口腔発癌モデル |
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| Outline of Final Research Achievements |
The purpose of this study is to establish non-invasive detection of oral precancerous lesion and early cancer by molecular imaging system. For new biomarker, we paid attention to glucose transporter 1 (GLUT1) , which increase with increasing cancerous characteristics. The imaging tests were performed using 4-NQ0 induced rat tongue cancer model and a new biomarker Glu-1N-Cy5 which transported in the cells by GLUT1. As a result of the molecular imaging tests, we could not get any pathological information about rat tongue carcinogenesis comparing an existing biomarker fluorescein sodium. However, this study was suggested possibility of a new detection system of oral cancer if more sensitive detection device was developed.
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