| Project/Area Number |
15K11313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Irifune Masahiro 広島大学, 医歯薬保健学研究科(歯), 教授 (10176521)
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| Co-Investigator(Kenkyū-buntansha) |
兼松 隆 広島大学, 医歯薬保健学研究科(歯), 教授 (10264053)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | サブスタンスP / 脊髄後角組織 / イミプラミン / モルヒネ / プロポフォール / ケタミン / マイクロダイアリシス法 / 脊髄後根神経節培養細胞 / 脊髄後角組織スライス / セロトニン受容体リガンド / オピオイド受容体 / サブスタンスＰ / セロトニン受容体 / 不動化 |
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| Outline of Final Research Achievements |
Whether the selective serotonin receptor ligands inhibit or whether the general anesthetics enhance substance P (SP) release from cultured rat dorsa root ganglion (DRG) neurons or rat spinal cord chopped tissues was examined. Capsaicin increased SP release from cultured DRG cells in a concentration-dependent fashion. The intravenous general anesthetics propofol and ketamine and the opioid receptor agonist morphine did not affect the capsaicin-induced SP release. Also, capsaicin concentration-dependently increased SP release from rat spinal cord chopped tissues. Morphine concentration-dependently inhibited the capsaicin-induced SP release. High concentrations of propofol enhanced the SP release, but ketamine did not. As the selective serotonin uptake inhibitor imipramine concentration-dependently increased the SP release, this drug did not have antinociceptive action in this region.
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