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Bone regeneration using a hybrid-type artificial bone consisted of iPS cells and low crystalline carbonate apatite

Research Project

Project/Area Number 15K11315
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University (2016-2017)
The University of Tokushima (2015)

Principal Investigator

Nagai Hirokazu  東北大学, 歯学研究科, 准教授 (50282190)

Co-Investigator(Kenkyū-buntansha) 宮本 洋二  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (20200214)
玉谷 哲也  徳島大学, 病院, 講師 (30274236)
藤澤 健司  徳島大学, 病院, 講師 (40228979)
大江 剛  徳島大学, 病院, 助教 (60432762)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨再生医療 / 炭酸アパタイト / iPS細胞 / 骨再生 / コラーゲン
Outline of Final Research Achievements

In this study, we try to develop the bone regenerative therapy using a hybrid-type artificial bone consisted of human induced pluripotent stem (iPS) cells and low crystalline carbonate apatite (CAp). We used iPS cells for cell source of bone regenerative therapy, and used low crystalline CAp and collagen complex for scaffold of bone regenerative therapy. As a result, it was revealed that 1) low crystalline CAp and collagen complex implanted into the cranial bone defect of rabbits induced new bone tissues, 2) the differentiation of human iPS cells to mesenchymal stem cell-like cells was induced, 3) mesenchymal stem cells cultured on carbonate apatite disk differentiated into osteoblastic cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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