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Development of novel therapeutic methods using Botox for masseter muscle pain

Research Project

Project/Area Number 15K11324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

NOMA Noboru  日本大学, 歯学部, 准教授 (70386100)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords慢性疼痛 / ION-CCI / P-ERK / ボツリヌス菌神経毒タイプA / 口腔顔面痛 / pERK-IR / ボトックス / 異常疼痛 / 三叉神経脊髄路核ニューロン
Outline of Final Research Achievements

We investigated the effect of botulinum neurotoxin type A (BoNT-A) on mechanical allodynia and hyperalgesia associated with infraorbital nerve constriction (ION-CCI) in rats. ION-CCI rats received a subcutaneous BoNT-A injection into the whisker pad area on day 7 postoperatively and underwent pain assessment on days 14 and 21 postoperatively. Rats were assigned to one of four treatment groups(n = 5 each): ION-CCI + BoNT-A 20 pg (low-dose group), ION-CCI + BoNT-A 200 pg (high-dose group), IONCCI+ saline, and Sham. Mechanical allodynia and hyperalgesia were evaluated preoperatively (baseline) and on days 7, 14, and 21 postoperatively. BoNT-A administration. The present findings suggest that, by suppressing Vc neuronal activity, high-dose intradermal injection of BoNT-A at the site of ION innervation alleviates mechanical facial allodynia and hyperalgesia associated with ION-CCI.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Botulinum neurotoxin type A alleviates mechanical hypersensitivity associated with infraorbital nerve constriction injury in rats.2017

    • Author(s)
      Noma N, Watanabe K, Sato Y, Imamura Y, Yamamoto Y, Ito R, Maruno M, Shimizu K, Iwata K.
    • Journal Title

      Neurosci Lett.

      Volume: 623 Pages: 96-101

    • DOI

      10.1016/j.neulet.2016.11.043

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Botulinum neurotoxin type A alleviates mechanical hypersensitivity associated with infraorbital nerve constriction injury in rats.2017

    • Author(s)
      Noma N, Watanabe K, Sato Y, Imamura Y, Yamamoto Y, Ito R, Maruno M, Shimizu K, Iwata K.
    • Journal Title

      Neurosci Lett

      Volume: 10 Pages: 96-101

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] BOTULINUM NEUROTOXIN TYPE A ALLEVIATES MECHANICAL HYPERSENSITIVITY ASSOCIATED WITH INFRAORBITAL NERVE CONSTRICTION INJURY IN RATS2017

    • Author(s)
      Noma N, Watanabe K, Imamura Y, Iwata K
    • Organizer
      Neuropathic Pain (NeuPSIG)2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Injection of Botulinum Neurotoxin type A alleviates Neuropathic Orofacial Pain2016

    • Author(s)
      野間 昇、今村佳樹
    • Organizer
      米国口腔内科学会2016
    • Place of Presentation
      アメリカ(アトランタ)
    • Year and Date
      2016-04-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Injection of Botulinum Neurotoxin Type A alleviates Neuropathic Orofacial Pain2016

    • Author(s)
      Noboru Noma, Yoshiki Imamura
    • Organizer
      The American Academy of Oral Medicine 2016
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2016-04-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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