A study of the impaired pain modulation system in the brain of BMS patients
Project/Area Number |
15K11326
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Nihon University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
篠崎 貴弘 日本大学, 歯学部, 講師 (50339230)
岩田 幸一 日本大学, 歯学部, 教授 (60160115)
野間 昇 日本大学, 歯学部, 准教授 (70386100)
岡田 明子 日本大学, 歯学部, 准教授 (10434078)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | バーニングマウス症候群 / 機能脳科学 / fMRI / QST / BMS / 脳コネクティビティ / Voxel Based Morphometry / 灰白質体積 / 帯状回 / 機能的MRI / 時間的加重 / 慣れ / 下行性疼痛調節 |
Outline of Final Research Achievements |
The pain modulation system in the brain of the BMS patients was investigated using quantitative sensory testing and functional MRI to clarify the pathophysiology of BMS which is one of the most typical orofacial pain with unknown origin. In BMS patients, temporal and spatial summation is facilitated as compared to healthy controls, in which impaired pain modulation system of the brain is involved. Habituation was less significant in BMS patients when noxious heat stimulation was applied at the lower lip. BMS patients report pain reduction after gum chewing. At this moment, BMS patients showed facilitated activity of the Dorsal Attention Network and increased connectivity between the thalamus and the inferior frontal gyrus (pars opercularis).
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Spatial and Temporal Brain Responses to Noxious Heat Thermal Stimuli in Burning Mouth Syndrome2016
Author(s)
Shinozaki T, Imamura Y, Kohashi R, Dezawa K, Nakaya Y, Sato Y, Watanabe K, Morimoto Y, Shizukuishi T, Abe O, Haji T, Tabei K and Taira M.
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Journal Title
Journal of Dental Research
Volume: 95
Pages: 1138-1146
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Short-term surgical effects of orthognathic surgery on somatosensory function and recovery patterns in the early postoperative period2016
Author(s)
Dezawa, K., Noma, N., Watanabe, K., Sato, Y., Kohashi, R., Tonogi, M., Heir, G., Eliav, E. and Imamura, Y.
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Journal Title
J Oral Sci
Volume: 58
Pages: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue2016
Author(s)
Nakaya, Y., Tsuboi, Y., Okada-Ogawa, A., Shinoda, M., Kubo, A., Chen, J., Noma, N., Batbold, D., Imamura, Y., Sessle, B. and Iwata, K.
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Journal Title
Mol Pain
Volume: in press
Pages: in press
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Headache Attributed to Temporomandibular Disorders and Masticatory Myofascial Pain: Temporal Relation to Physical Therapy for Temporomandibular Disorders2016
Author(s)
Hara, K., Shinozaki, T., Okada-Ogawa, Q., Matsukawa, Y., Dezawa, K., Nakaya, Y., Chen, J., Noma, N., Oka, S., Iwata, K. and Imamura, Y.
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Journal Title
J Oral Sci
Volume: 58
Pages: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Basic research and clinical investigations of the neural basis of orofacial pain2015
Author(s)
Matsuka, Y., Iwata, K., Terayama, R., Imamura, Y., Maruhama, K., Shinoda, M. Tsuboi Y., Kondo, M., Honda, K. Katagiri, A. & Sugimoto, T.
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Journal Title
J Oral Biosci
Volume: 57
Pages: 27-36
DOI
Related Report
Peer Reviewed
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