Immunological analysis of pathogenesis and immune response in titanium allergy
| Project/Area Number |
15K11329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
熊谷 賢一 鶴見大学, 歯学部, 助教 (10518129)
鈴木 隆二 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療研究室, 室長 (70373470)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | チタンアレルギー / TCR / T細胞受容体 / NK T細胞 / MAIT細胞 / 金属アレルギー |
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| Outline of Final Research Achievements |
Titanium alloy has long been regarded as a biocompatible material, and is widely used for implants in medicine and dentistry. Titanium is thought to be a potential cause of metal allergy, however, accumulating T cells during development of titanium allergy have been poorly characterized because basic research based on a suitable animal model has not been performed. This study aimed to investigate the skewing of the T-cell receptor repertoire and cytokine profiles of accumulated T cells in inflamed skin during titanium allergy.Characterization of the TCR repertoire revealed the presence of the TRAV10/TRAJ18 clonotype, indicative of natural killer T cells, and TRAV1/TRAJ33, associated with mucosal-associated invariant T (MAIT) cells in the inflamed skin of both the irritant and allergic mice models. Thus our murine model of titanium-induced hypersensitivity shows that NKT cells and MAIT cells participate in titanium allergy.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis.2016
Author(s)
Kumagai K, Horikawa T, Shigematsu H, Matsubara R, Kitaura K, Eguchi T, Kobayashi H, Nakasone Y, Sato K, Yamada H, Suzuki S, Hamada Y, Suzuki R.
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Journal Title
International journal of molecular sciences
Volume: 12
Issue: 1
Pages: 87-87
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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