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The immunomodulatory effects of anesthetics in cancer microenvironment leading to cancer malignancy

Research Project

Project/Area Number 15K11331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAsahi University

Principal Investigator

Kamiya Masako  朝日大学, 経営学部, 准教授 (80181907)

Co-Investigator(Kenkyū-buntansha) 近藤 信夫  朝日大学, 歯学部, 教授 (40202072)
智原 栄一  朝日大学, 歯学部, 教授 (80244581)
山崎 裕  北海道大学, 歯学研究院, 教授 (90250464)
村松 泰徳  朝日大学, 歯学部, 教授 (30247556)
高山 英次  朝日大学, 歯学部, 准教授 (70533446)
川木 晴美  朝日大学, 歯学部, 准教授 (70513670)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords麻酔薬 / 抗腫瘍免疫 / 癌組織内微小環境 / 口腔扁平上皮癌 / 免疫抑制 / 局所麻酔薬 / 静脈麻酔薬 / 免疫 / サイトカイン / 免疫応答 / 悪性腫瘍 / インターフェロンγ / 癌微小環境
Outline of Final Research Achievements

To clarify the effects of the anesthetics on the tumor microenvironment, we evaluated their cytotoxicity against oral squamous cell carcinoma (OSCC) cells, stromal cells (10T1/2) and mouse spleen cells and the influence on immuno-response of these cells.
The all of anesthetics tested showed cytotoxic effects on spleen cells at much lower concentrations than on the OSCC cells and 10T1/2, which suggests that spleen cells are more sensitive against anesthetics than the other cell lines. The cytokine-production by anti-CD3-stimulated spleen cells was completely inhibited at a lower concentration of intravenous anesthetics, whereas spleen cells maintained a 80-100% viability. In addition, only midazolam inhibited the immunosuppressive action of 10T1/2. On the other hand, in animal experiments with tumor-bearing mice, it was suggested that intravenous anesthetics could inhibit the development of tumor.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (12 results)

  • [Journal Article] Suppressive effect of mesenchymal stromal cells on interferon-γ-producing capability of spleen cells was specifically enhanced via humoral mediator(s) from mouse oral squamous cell carcinoma Sq-1979 cells in vitro.2018

    • Author(s)
      Inagaki T, Mizuno-Kamiya M, Takayama E, Kawaki H, Chihara E, Muramatsu Y, Sumitomo S, Kondoh N.
    • Journal Title

      Cancer Transl Med

      Volume: 4 Issue: 1 Pages: 9-16

    • DOI

      10.4103/ctm.ctm_34_17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene expression analyses associated with malignant phenotypes of metastatic sub-clones derived from a mouse oral squamous cell carcinoma Sq-1979 cell line2018

    • Author(s)
      Adachi Mitsutaka、Mizuno?Kamiya Masako、Takayama Eiji、Kawaki Harumi、Inagaki Toshihiro、Sumi Shigeki、Motohashi Masayuki、Muramatsu Yasunori、Sumitomo Shin?Ichiro、Shikimori Michio、Yamazaki Yutaka、Kondoh Nobuo
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 3350-3356

    • DOI

      10.3892/ol.2017.7648

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The producing capabilities of Interferon-g and Interleukin-10 of spleen cells in primary and metastasized oral squamous cell carcinoma cells-implanted mice.2017

    • Author(s)
      Azuma Y, Mizuno-Kamiya M, Takayama E, Kawaki H, Inagaki T, Chihara E, Muramatsu Y, and Kondoh N.
    • Journal Title

      Transl Med

      Volume: 3 Issue: 6 Pages: 194-199

    • DOI

      10.4103/ctm.ctm_30_17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells2017

    • Author(s)
      Shigeki Sumi, Naoki Umemura, Eiji Takayama, Emika Ohkoshi, Makoto Adachi, Masako Mizuno-Kamiya, Toshihiro Inagaki, Harumi Kawaki, Shinichiro Sumitomo and Nobuo Kondoh
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 37 Issue: 5 Pages: 2897-2904

    • DOI

      10.3892/or.2017.5575

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tumor growth limited to a single site vs tumor growth in multiple sites exhibit differential effects on systemic immunities2017

    • Author(s)
      Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjyo Y, Ichinohe T, Tokuno S, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H., Mizuno-Kamiya M, Kondoh N, Seno M
    • Journal Title

      Oncology Reports

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Immunosuppression Effect by Adipose Tissue-derived Mesenchymal Stem Cells Isolated from β2-microglobulin Deficient mice2017

    • Author(s)
      Masuda J, Takayama E, Ichinohe T, Strober W, Mizuno-Kamiya M, Ikawa T, Kitani A, Kawaki H, Fuss IJ, Kawamoto H, Seno A, Vaidyanath A, Umemura N,  Mizutani A, Kasai T, Honjo Y, Satoh A, Murakami H, Katsura Y, Kondoh N, Seno M.
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 局所麻酔薬が腫瘍組織の微小環境における免疫応答におよぼす影響2017

    • Author(s)
      稲垣慶則, 神谷真子, 梅村直己, 川木晴美, 高山英次, 伊藤宏衣, 鷲見成紀, 櫻井 学, 智原栄一, 近藤信夫
    • Organizer
      第37回日本歯科薬物療法学会・学術大会(名古屋)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 静脈麻酔薬が口腔扁平上皮癌組織微小環境における免疫制御におよぼす影響2017

    • Author(s)
      稲垣慶則, 神谷真子, 梅村直己, 川木晴美, 高山英次, 伊藤宏衣,住友信一郎, 櫻井 学, 智原栄一, 近藤信夫
    • Organizer
      第59回歯科基礎医学会総会学術大会(塩尻)
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス口腔扁平上皮癌細胞株(Sq1979)のIL-1αによる間葉系細胞(10T1/2)を介した免疫抑制機構2017

    • Author(s)
      伊藤宏衣,神谷真子,川木晴美,高山英次,梅村直己,稲垣慶則,村松泰徳,住友伸一郎,近藤信夫
    • Organizer
      第59回歯科基礎医学会総会学術大会(塩尻)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の原発巣と転移巣における骨髄由来免疫抑制細胞の検討2016

    • Author(s)
      鷲見成紀,梅村直己,高山英次,伊藤宏衣,神谷真子,川木晴美,近藤信夫,住友伸一郎
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス口腔扁平上皮癌細胞株(Sq1979)の液性因子による間葉系細胞(10T1/2)を介した免疫抑制作用の促進2016

    • Author(s)
      伊藤宏衣,神谷真子,鷲見成紀,川木晴美,高山英次,梅村直己,稲垣慶則,村松泰徳,住友伸一郎,近藤信夫
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 麻酔薬が癌組織微小環境における免疫制御におよぼす影響2016

    • Author(s)
      稲垣慶則, 神谷真子, 梅村直己, 川木晴美, 高山英次, 伊藤宏衣, 鷲見成紀, 櫻井 学, 智原栄一, 近藤信夫
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス口腔扁平上皮癌と脾細胞の共培養系におけるサイトカイン産生能の検討2015

    • Author(s)
      稲垣俊弘, 川木晴美, 髙山英次, 伊藤宏衣, 鷲見成紀, 足立充隆, 住友伸一郎, 村松泰徳,近藤信夫
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] C3Hマウス間葉系細胞(10T1/2)を介した口腔扁平上皮癌細胞株(Sq1979)によるCcl2の調節2015

    • Author(s)
      伊藤宏衣,足立充隆,稲垣俊弘,鷲見成紀,江原雄一,村松泰徳,式守道夫,髙山英次,近藤信夫,住友伸一郎
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス口腔扁平上皮癌細胞株(Sq1979)のリンパ節転移巣由来サブクローン(L細胞)によるTh1型免疫反応の促進;その制御因子の同定と機能解析2015

    • Author(s)
      足立充隆,神谷真子,川木晴美,髙山英次,稲垣俊弘,伊藤宏衣,鷲見成紀,村松泰徳,住友伸一郎,近藤信夫
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス口腔扁平上皮癌の悪性形質獲得に伴う脾細胞の抗腫瘍免疫応答の変化2015

    • Author(s)
      鷲見成紀,神谷真子,川木晴美,髙山英次,伊藤宏衣,足立充隆,稲垣俊弘,村松泰徳,住友伸一郎,近藤信夫
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス口腔扁平上皮癌細胞株(Sq1979)の液性因子による間葉系細胞(10T1/2)を介したc-c motif chemokine 2(Ccl2)発現の誘導2015

    • Author(s)
      伊藤宏衣,足立充隆,神谷真子,川木晴美,髙山英次,稲垣俊弘,鷲見成紀,村松泰徳,住友伸一郎,近藤信夫
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス口腔扁平上皮癌の悪性化にともなう脾細胞のサイトカイン産生能の改変機構2015

    • Author(s)
      稲垣俊弘,神谷真子,川木晴美,髙山英次,伊藤宏衣,鷲見成紀,足立充隆,住友伸一郎,村松泰徳,近藤信夫
    • Organizer
      第57回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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