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Elucidation of the structural change-related factor in the bone microenvironment

Research Project

Project/Area Number 15K11332
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionHyogo Medical University

Principal Investigator

TAKAOKA KAZUKI  兵庫医科大学, 医学部, 講師 (60373122)

Co-Investigator(Kenkyū-buntansha) 浦出 雅裕  兵庫医科大学, 医学部, 特別招聘教授 (70104883)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords骨微小環境 / 破骨前駆細胞 / TGF-β / 骨簿小環境
Outline of Final Research Achievements

Osteoclasts (OC) are differentiated from monocyte/macrophage-lineage hematopoietic precursor cells which were termed OC precursors (OCPs). The aim of this study was to determine the effects of TGF-β on migration of OCPs in the bone microenvironment using the pre-osteoclastic RAW264.7 cells. Cell migration was significantly increased by treatment of TGF-β1 on 24 h, but was decreased by 72 h of treatment. These findings suggest that the migration of OCPs was enhanced by TGF-β1 at early stages of osteoclast differentiation, and at later stages differentiated cells showed low migration. The cell migration change might be caused by osteoclast differentiation. Subsequently, migration gradually decreases following differentiation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Effect of TGF-β1 on osteoclast precursors in the bone microenvironment2018

    • Author(s)
      Miho Ueta, Kazuki Takaoka, Joji Tamaoka, Hanako Maeda, Michiyo Nishida, Kazuma Noguchi, Hiromitsu Kishimoto
    • Organizer
      2018 American Association for Dental Research/Canadian Association for Dental Research Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Osteonecrosis induction using bisphosphonate and oxidative stress inducer in mice2018

    • Author(s)
      Joji Tamaoka, Kazuki Takaoka, Miho Ueta, Hirokazu Hattori, Kazuma Noguchi, Hiromitsu Kishimoto
    • Organizer
      2018 American Association for Dental Research/Canadian Association for Dental Research Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨微小環境における破骨前駆細胞の分化に伴う細胞運動能の変化2017

    • Author(s)
      上田 美帆,高岡 一樹,荒木 華子,玉岡 丈二,川邊 睦記,野口 一馬,岸本 裕充
    • Organizer
      第71回NPO法人日本口腔科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨微小環境における破骨前駆細胞の分化に伴う細胞運動能の変化2017

    • Author(s)
      上田 美帆,高岡 一樹,前田 華子,野口 一馬,岸本 裕充
    • Organizer
      第54回日本口腔組織培養学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨微小環境における破骨前駆細胞の遊走,定着機構の解明2016

    • Author(s)
      上田 美帆,高岡 一樹,荒木 華子,玉岡 丈二,川邊 睦記,野口 一馬,岸本 裕充
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ(千葉市,千葉県)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨微小環境における破骨前駆細胞の分化に伴う細胞運動能の変化2016

    • Author(s)
      上田 美帆,高岡 一樹,野口 一馬,岸本 裕充
    • Organizer
      第53回日本口腔組織培養学会総会・学術大会
    • Place of Presentation
      石川県立美術館(金沢市,金沢県)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] The effect of TGF-β1 on osteoclast precursors in the bone microenvironment2016

    • Author(s)
      Tamaoka J, Takaoka K, Ueta M, Araki H, Noguchi K, Kishimoto H.
    • Organizer
      23rd Congress of the European Association for Cranio Maxillo-Facial Surgery
    • Place of Presentation
      The Queen Elizabeth Ⅱ Conference Centre (London, UK)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨微小環境における細胞外物理的環境変化によるHippoシグナルの関与2016

    • Author(s)
      上田 美帆,高岡 一樹,荒木 華子,玉岡 丈二,川邊 睦記,野口 一馬,岸本 裕充
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県,福岡市)
    • Year and Date
      2016-04-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨微小環境におけるTGF-βの破骨前駆細胞への影響2015

    • Author(s)
      西田倫世,高岡一樹,川邊睦記,荒木華子,玉岡丈二,野口一馬,岸本裕充
    • Organizer
      第60回公益社団法人日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県,名古屋市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Effect of TGF-β1 on osteoclast precursors in the bone microenvironment2015

    • Author(s)
      Tamaoka Joji, Takaoka Kazuki, Nishida Michiyo, Araki Hanako, Noguchi Kazuma, Kishimoto Hiromitsu
    • Organizer
      ADR ANZ Division 55th Annual Scientific Meeting
    • Place of Presentation
      Dunedin, New Zealand
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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