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Approach to a quantitative method for evaluating the facial characteristics of patients with congenital anomalies for analyzing genome to phenome correlations

Research Project

Project/Area Number 15K11340
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TSUJI Michiko  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (90345281)

Co-Investigator(Kenkyū-buntansha) 馬場 祥行  東京医科歯科大学, 歯学部, 非常勤講師 (70251535)
鈴木 聖一  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (90187732)
Project Period (FY) 2015-10-21 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords先天異常疾患 / バーチャルフェイス / 定量的評価 / 非接触型三次元顔面形状計測 / 特異的顔貌
Outline of Final Research Achievements

The purpose of this study was to quantitatively define the facial characteristics of patients with congenital anomalies by constructing a virtual face and comparing it to that of non-syndromic subjects. The congenital anomaly group composed of Turner syndrome patients and the control group composed of non-syndromic subjects. Three-dimensional photographs were acquired from both groups using a non-contact three dimensions digitizer. Homologous models were constructed from the three-dimensional photographs using a three-dimensional shape analysis software.
From the homologous model, virtual faces of the two groups were compared by the averaged face technique. It revealed that in the congenital anomaly group, more protrusion of the subnasale to the upper lip, lower height of the apex of nose, deeper mentolabial sulcus and more mandibular retrusion particularly mentum region.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (23 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 4 results) Book (2 results)

  • [Journal Article] Williams症候群患者における顎顔面形態と口腔内の特徴2018

    • Author(s)
      浅見拓也, 辻美千子, 庄司あゆみ, 疋田理奈, 馬場祥行, 森山啓司
    • Journal Title

      Orthodontic Waves(Japanese Edition)

      Volume: 77(1) Pages: 9-16

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of Maxillofacial Morphology and Oral Characteristics with Turner Syndrome and Early Mixed Dentition2018

    • Author(s)
      Ahiko Nozomi、Baba Yoshiyuki、Tsuji Michiko、Horikawa Reiko、Moriyama Keiji
    • Journal Title

      Congenital Anomalies

      Volume: 印刷中 Issue: 1 Pages: 11-17

    • DOI

      10.1111/cga.12284

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic and maxillofacial characteristics of eleven Japanese children with Russell–Silver syndrome.2016

    • Author(s)
      Sato C, Ogawa T, Tsuge R, Shiga M, Tsuji M, Baba Y, Kosaki K, Moriyama K.
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: - Issue: 5 Pages: 217-225

    • DOI

      10.1111/cga.12162

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Down症候群患者の口腔顎顔面部における臨床的特徴 ー骨格系ならびに永久歯の先天性欠如に関する検討ー2015

    • Author(s)
      池田倫世、辻美千子、大宅彩、小川卓也、森山啓司.
    • Journal Title

      日本矯正歯科学会雑誌

      Volume: 74(2) Pages: 67-77

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Analysis of palatal morphology in craniosynostosis patients: Comparison between Apert syndrome and Crouzon syndrome2018

    • Author(s)
      Ogura K., Kobayashi Y., HikitaR., Shoji A., Tsuji M., Moriyama K
    • Organizer
      Asian Pacific Orthodontic Congress 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 頭蓋縫合早期癒合症患者の口蓋形態の三次元的解析 -アペール症候群とクルーゾン症候群の比較-2017

    • Author(s)
      小倉健司、小林起穂、疋田理奈、庄司あゆみ、辻美千子、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stickler症候群とRobin sequence患者の臨床症状の比較 -頭蓋顎顔面形態と全身症状に着目して-2017

    • Author(s)
      早川大地、幸田直己、高橋由記、姜順花、松本英和、ネイ ミョ ミン スイ、辻美千子、 小林起穂、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 矯正歯科治療により咬合改善を行ったアペール症候群2症例におけるビザンチン口蓋の長期的形態変化2017

    • Author(s)
      小倉健司、小林起穂、疋田理奈、辻美千子、森山啓司
    • Organizer
      第57回日本先天異常学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stickler症候群患者の口腔内の特徴に関する検討2017

    • Author(s)
      木下由紀子、高橋由記、幸田直己、齋藤小百合、宮崎貴行、ピョ ティハ 辻美千子、小林起穂、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口唇裂 口蓋裂を伴う希少遺伝性疾患 患者の矯正歯科治療に関する実態調査2017

    • Author(s)
      小川卓也、伴田みさと、上園将慶、駒崎裕子、辻美千子、森山啓司
    • Organizer
      第41回日本口蓋裂学会総会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 過去10年間に当分野を受診した埋伏歯を有する患者の臨床統計学的検討2017

    • Author(s)
      林婉テイ、辻美千子、庄司あゆみ、東堀紀尚、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成長終了後に下顎頭肥大を呈したStickler症候群の1症例2017

    • Author(s)
      富永千慧、幸田直己、高橋由記、門脇佳緒里、小倉健司、辻美千子、小林起穂、森山啓司
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭蓋縫合早期癒合症(Craniosynostosis)患者の顎顔面形態の解析―アペール症候群とクルーゾン症候群の比較2016

    • Author(s)
      小林起穂、辻美千子、疋田理奈、小倉健司、森山啓司
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティ徳島(徳島県、徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Maxillofacial morphology of 4 cases of Marfan-related diseases in mixed dentition stage2016

    • Author(s)
      BabaY, Komazaki Y, Miyamoto J, Ogura K, Ahiko N, Baba Y, Tsuji M, Moriyama
    • Organizer
      The 49th Annual Scientific Congress, Korean Association of Orthodontists
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭蓋縫合早期癒合症(Craniosynostosis)患者の顎顔面形態の解析 -アペール症候群とクルーゾン症候群の比較.2016

    • Author(s)
      小林起穂、辻美千子、疋田理奈、小倉健司、森山啓司
    • Organizer
      第56回日本先天異常学会学術集会
    • Place of Presentation
      姫路商工会議所(兵庫県、姫路市)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Research-status Report
  • [Presentation] Maxillofacial morphological characteristics of two Japanese patients with chromosome 18p deletion syndrome2016

    • Author(s)
      Tsuji M, Ogura K, Hikita R, Kobayashi Y, Moriyama K
    • Organizer
      ICHG2016(The 13th International Congress of Human Genetics)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto,Japan
    • Year and Date
      2016-04-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Systemic and craniomaxillofacial characteristics of patients with Williams syndrome2016

    • Author(s)
      Hikita R, Matsuno S, Asami T, Ogawa T, Baba Y, Tsuji M, Moriyama K
    • Organizer
      ICHG2016(The 13th International Congress of Human Genetics)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto,Japan
    • Year and Date
      2016-04-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 当分野を受診した18p-症候群2症例の顎顔面形態の特徴2015

    • Author(s)
      小倉健司、辻美千子、疋田理奈、小林起穂、森山啓司.
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 鎖骨頭蓋異形成症患者における埋伏歯の形態および位置の三次元的評価2015

    • Author(s)
      鈴木尋之、辻美千子、鈴木聖一、森山啓司
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 矯正歯科外来において長期管理を行った先天性ミオパチー3例2015

    • Author(s)
      伴田みさと、伊藤洋介、渡辺千穂、辻美千子、小川卓也、森山啓司
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋原性疾患患者における頭蓋顎顔面形態の特徴について-先天性ミオパチーと筋ジストロフィーの比較.2015

    • Author(s)
      中村留理子、荒木美祐、渡辺千穂、伊藤 洋介、小笠原 毅、辻幸佑、山形義紘、辻美千子、小川 卓也、森山 啓司
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Book] 矯正臨床ジャーナル:東京医科歯科大学歯科講演会『顎顔面矯正学の現在と未来-顎顔面矯正学分野のめざすもの』-7先天異常疾患に対する顎顔面矯正学的な対応2017

    • Author(s)
      辻美千子
    • Total Pages
      129
    • Publisher
      東京臨床出版
    • Related Report
      2017 Annual Research Report
  • [Book] 顏の百科事典、日本顏学会編2015

    • Author(s)
      辻 美千子
    • Total Pages
      640
    • Publisher
      丸善出版
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-10-21   Modified: 2019-03-29  

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