| Project/Area Number |
15K11346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
片岡 伴記 岡山大学, 医歯薬学総合研究科, 助教 (50580180)
住吉 久美 岡山大学, 医歯薬学総合研究科, 助教 (80625161)
中村 政裕 岡山大学, 大学病院, 助教 (20708036)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヒト歯根膜幹細胞 / RNA検出プローブ / ＲＮＡ検出プローブ |
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| Outline of Final Research Achievements |
The purpose of this research is to investigate RNAs specifically expressed in human periodontal stem cells, and to establish a method to efficiently isolate human periodontal stem cells as living cells using RNA detection probes. As a result, LRIG1 was identified as one of the RNAs specifically expressed in human periodontal stem cells. In addition, as a result of comparison between LRIG1 positive and LRIG1 negative human periodontal ligament cells using LRIG1 RNA detection probes, LRIG1 positive human periodontal ligament cells have higher cell proliferative capacity, and adipogenic and osteogenic differentiation capacity in vitro was also high. Therefore, it was suggested that LRIG1 is useful for identification of human periodontal stem cells.
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