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Evaluation of a Proton Pump Inhibitor for Sleep Bruxism

Research Project

Project/Area Number 15K11350
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionKagoshima University

Principal Investigator

OMURE Haruhito  鹿児島大学, 医歯学総合研究科, 客員研究員 (00404484)

Co-Investigator(Kenkyū-buntansha) 宮脇 正一  鹿児島大学, 医歯学域歯学系, 教授 (80295807)
永山 邦宏  鹿児島大学, 医歯学域附属病院, 助教 (60583458)
高田 寛子  鹿児島大学, 医歯学総合研究科, 客員研究員 (80634229)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords睡眠時ブラキシズム / 胃食道逆流 / GERD / 胃酸分泌抑制剤 / PPI / 薬物療法 / ブラキシズム / プロトンポンプ阻害薬
Outline of Final Research Achievements

We aimed to assess the efficacy of a proton pump inhibitor (PPI) on sleep bruxism (SB) and to examine the symptoms and condition of upper gastrointestinal (GI) tract in SB patients. Twelve SB patients underwent an assessment of GI symptoms and endoscopy. At baseline, the mean frequencies of EMG bursts and RMMA episodes were 65.4 and 7.0 times/h, respectively, and at least one grinding noise was confirmed in all participants. The mean FSSG score was 8.4, and 41.7% of patients were diagnosed with GERD. Reflux esophagitis was confirmed in 6 patients. Polysomnography were performed on days 4 and 5 of administration of the PPI (rabeprazole) or placebo. PPI administration yielded a significant reduction in the frequency of EMG bursts, RMMA episodes, and grinding noise. No significant differences were observed regarding the swallowing events and sleep variables. The results of this trial highlight the potential application of pharmacological GERD treatment for SB patients.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Evaluation of a Proton Pump Inhibitor for Sleep Bruxism: A Randomized Clinical Trial2016

    • Author(s)
      H. Ohmure, K. Kanematsu-Hashimoto, K. Nagayama, H. Taguchi, A. Ido, K. Tominaga3, T. Arakawa, and S. Miyawaki
    • Journal Title

      Journal of Dental Research

      Volume: 95 Issue: 13 Pages: 1479-1486

    • DOI

      10.1177/0022034516662245

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 睡眠時ブラキシズムに対するプロトンポンプ阻害剤の効果 -ランダム化臨床試験-2017

    • Author(s)
      橋本 恭子、大牟禮 治人、永山 邦宏、宮脇 正一
    • Organizer
      九州矯正歯科学会
    • Place of Presentation
      New Wel City宮崎(宮崎県宮崎市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠時ブラキシズムに対するプロトンポンプ阻害剤の効果‐ランダム化臨床試験‐2017

    • Author(s)
      橋本恭子, 大牟禮治人, 永山邦宏, 宮脇正一
    • Organizer
      第12回九州矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クレンチング時の脳賦活部位の左右差についての検討:fMRI を用いた研究2015

    • Author(s)
      永山邦宏,末永重明,大牟禮治人,福嶋美佳,丸谷佳菜子,宮脇正一
    • Organizer
      日本矯正歯科学会第74回学術大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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