| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The aim of the present study was to investigate the functional role of neuron-glial cells crosstalk within the trigeminal ganglia on the enhancement of neuronal excitability of trigeminal ganglion in experimentally tooth-movement (ETM) rat, using behavioral, electrophysiological and immunohistochemical studies. In the present study, we established ETM rat model for examining orthodontic pain. Behavioral analysis revealed that occurrence of spontaneous pain and ectopic hyperalgesia in the whisker pad area was observed in the maxillary ETM rat. Electrophysiological study demonstrated that mechanical discharge frequency of trigeminal spinal nucleus caudalis neurons in the ETM rats was significantly increased due to the decrement of mechanical stimulus threshold. Taken together, these findings strongly suggest that neuron-glial cells crosstalk within the trigeminal ganglia may contribute to the ETM-induced ectopic inflammatory hyperalgesia.
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