| Project/Area Number |
15K11363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Nomura Ryota 大阪大学, 歯学研究科, 准教授 (90437385)
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| Co-Investigator(Kenkyū-buntansha) |
仲 周平 岡山大学, 大学病院, 講師 (10589774)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔細菌 / 感染性心内膜炎 / コラーゲン結合タンパク（CBP） / タンパク抗原（PA） / ex vivo評価系 / ウシ心臓弁 / ラット感染性心内膜炎モデル / 血清 / Streptcoccus mutans / コラーゲン結合タンパク / タンパク抗原 / Ⅳ型コラーゲン / 補体 / Streptococcus mutans / う蝕 / 菌血症 / 細菌塊 / 血管内皮細胞 / IV型コラーゲン / 歯髄細胞 / 感染根管治療 / 低分子量Gタンパク |
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| Outline of Final Research Achievements |
To analyze the pathogenesis of IE induced by Streptococcus mutans strains with different patterns of expression of a 120-kDa collagen-binding protein (CBP) and 190-kDa protein antigen (PA), we focused on adhesion of the bacterium to human pulp cells and its interaction with liquid components in blood. CBP-positive S. mutans strains had a high level of adhesion to human pulp cells, while CBP+/PA- strains showed aggregation in the presence of serum, which may contribute to the pathogenicity of IE.
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