Interdisciplinary research for elucidating mechanisms of infective endocarditis onset and development with focus on oral bacteria and host defense interactions
Project/Area Number |
15K11363
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Osaka University |
Principal Investigator |
Nomura Ryota 大阪大学, 歯学研究科, 准教授 (90437385)
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Co-Investigator(Kenkyū-buntansha) |
仲 周平 岡山大学, 大学病院, 講師 (10589774)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 口腔細菌 / 感染性心内膜炎 / コラーゲン結合タンパク(CBP) / タンパク抗原(PA) / ex vivo評価系 / ウシ心臓弁 / ラット感染性心内膜炎モデル / 血清 / Streptcoccus mutans / コラーゲン結合タンパク / タンパク抗原 / Ⅳ型コラーゲン / 補体 / Streptococcus mutans / う蝕 / 菌血症 / 細菌塊 / 血管内皮細胞 / IV型コラーゲン / 歯髄細胞 / 感染根管治療 / 低分子量Gタンパク |
Outline of Final Research Achievements |
To analyze the pathogenesis of IE induced by Streptococcus mutans strains with different patterns of expression of a 120-kDa collagen-binding protein (CBP) and 190-kDa protein antigen (PA), we focused on adhesion of the bacterium to human pulp cells and its interaction with liquid components in blood. CBP-positive S. mutans strains had a high level of adhesion to human pulp cells, while CBP+/PA- strains showed aggregation in the presence of serum, which may contribute to the pathogenicity of IE.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study.2016
Author(s)
Tonomura S, Ihara M, Kawano T, Tanaka T, Okuno Y, Saito S, Friedland RP, Kuriyama N, Nomura R, Watanabe Y, Nakano K, Toyoda K, Nagatsuka K.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 20074-20074
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans.2015
Author(s)
Miyatani F, Kuriyama N, Watanabe I, Nomura R, Nakano K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Mizuno T, Tamura A, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Ihara M, Kanamura N, Friedland RP, Watanabe Y.
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Journal Title
Oral Diseases
Volume: 21
Issue: 7
Pages: 886-893
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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