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Examination of optimum concentration of fluoride ion in saliva and control method in infants

Research Project

Project/Area Number 15K11375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

Uchikawa Yoshimori  日本歯科大学, 生命歯学部, 教授 (00176679)

Research Collaborator YAMAZAKI TERUMI  
SHIRASE TOSHIOMI  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords幼児 / 唾液 / フッ化物イオン濃度 / フローインジェクション分析装置 / う蝕原性細菌 / 口腔衛生習慣 / フッ化物 / アンケート / 歯科口腔保健 / イオン濃度 / う蝕 / ミュータンスレンサ球菌 / 生活習慣 / 齲蝕原性細菌
Outline of Final Research Achievements

Understanding the fluoride (F) ion concentration in saliva can confirm the environment surrounding the tooth, in particular, the caries resistance, and can also evaluate the use status of F preparation. We measured the F ion concentration in the saliva of Japanese infants aged 4 - 5 years using a flow injection analyzer. The average value was 0.0082 (maximum: 0.017; minimum: 0.0025) ppm. The results confirmed the need for F preparation use in Japanese infants.
The association between infants' lifestyle and the F ion concentration in saliva was examined. The salivary F ion concentration was associated with the brushing habit but not with the salivary level of cariogenic bacteria in infants.

Academic Significance and Societal Importance of the Research Achievements

本研究は、フローインジェクション分析装置を用いて日本人幼児の唾液中のフッ化物(F)イオン濃度の平均値は0.0082ppmF(最大 0.017、最小0.0025ppm)であったことを報告した。これは、Fのう蝕予防効果として期待される脱灰の抑制や再石灰化の促進に必要な歯の周囲のFイオン濃度0.014-0.02ppmにさえも達していない。このことから、日本人幼児においてう蝕予防を目的としてF製剤の使用を積極的に推進する根拠を示せた。また、口腔衛生習慣との関連性から、歯みがきとの関連性が挙げられ、F製剤を用いて歯みがきを継続することによりう蝕予防効果が上がることを改めて示した。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Changes in salivary free fluoride ion concentration after adding low-concentration fluoride2016

    • Author(s)
      Terumi Iwasaki, Yoshimori Uchikawa
    • Journal Title

      JSM Dentistry

      Volume: 4 Pages: 1060-1064

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Salivary-free fluoride ion concentration measured using a flow-injection analysis device and oral environment in 4-6-year-old children.2015

    • Author(s)
      Iwasaki Terumi, Uchikawa Yoshimori, Shirase Toshiomi
    • Journal Title

      Odontology

      Volume: 22 Issue: 3 Pages: 1-8

    • DOI

      10.1007/s10266-015-0224-3

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Predicting caries in preschool children using salivary mutans streptococci2018

    • Author(s)
      Yoshimori Uchikawa, Terumi Yamazaki, Toshiomi Shirase
    • Organizer
      IADR General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Oral Behavior and Maintenance on Salivary Mutans Streptococci Levels in Infants2018

    • Author(s)
      Yoshimori Uchikawa, Terumi Yamazaki, Yuko Umezu , Toshiomi Shirase
    • Organizer
      The International Association of Paediatric Dentistry Global Summit on Early Childhood Caries
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predicting caries in preschool children using salivary mutans streptococci2017

    • Author(s)
      Uchikawa Y, Yamazaki T, Shirase T
    • Organizer
      FDI World Dental Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 幼児期のミュータンスレンサ球菌定着に影響する生活習慣について2016

    • Author(s)
      3.巻 竜也, 岩崎 てるみ, 梅津 糸由子, 白瀬 敏臣, 内川 喜盛
    • Organizer
      小児保健研究
    • Place of Presentation
      大宮ソニックシティ〔埼玉県さいたま市)
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Caries predictive ability for the salivary mutans streptococci level in preschool children.2016

    • Author(s)
      Yoshimori Uchikawa, Terumi Iwasaki, Hidenori Yoh
    • Organizer
      The American Association for Dental Research
    • Place of Presentation
      アメリカ、ロサンゼルス
    • Year and Date
      2016-03-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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