Application of modificomic technologies to discover and identify biomarkers for periodontal diseases
Project/Area Number |
15K11379
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
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Research Institution | Chiba University |
Principal Investigator |
Tsuchida Sachio 千葉大学, 医学部附属病院, 特任助教 (90410422)
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Co-Investigator(Kenkyū-buntansha) |
佐藤 守 千葉大学, 医学部附属病院, 特任准教授 (20401002)
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Co-Investigator(Renkei-kenkyūsha) |
Aoki Akira 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (30302889)
Kobayashi Hiroaki 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (50396967)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 歯学 / 歯周病学 / プロテオミクス / 質量分析計 / モディフィコミクス / 歯周疾患 / 質量分析技術 / MALDI-TOF MS |
Outline of Final Research Achievements |
Proteomics provides a better understanding of cells by elucidating the structure, function, and interactions of proteins. Furthermore, post-translational modification (PTM) of proteins is required to control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms, it is critical to profile the PTM-dependent protein- protein interactions. Our findings indicate that PTM of protein may be involved in the progression of periodontal disease and is a potential biomarker of periodontal disease. Further studies using a larger sample size are required to verify the findings of this study. In the future, phosphoproteomics and glycomics may be applied to the study of periodontal disease.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Assessment by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of the Effects of Preanalytical Variables on Serum Peptidome Profiles Following Long-Term Sample Storage.2018
Author(s)
Tsuchida S, Satoh M, Umemura H, Sogawa K, Takiwaki M, Ishige T, Miyabayashi Y, Iwasawa Y, Kobayashi S, Beppu M, Nishimura M, Kodera Y, Matsushita K, Nomura F
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Journal Title
Proteomics. Clinical applications
Volume: 15
Issue: 3
Pages: 47-53
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation.2016
Author(s)
Ishige T, Nishimura M, Satoh M, Fujimoto M, Fukuyo M, Semba T, Kado S, Tsuchida S, Sawai S, Matsushita K, Togawa A, Matsubara H, Kaneda A, Nomura F
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 21681-21681
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein α-chain (C4BPA) by quantitative proteomic analysis using tandem mass tags.2016
Author(s)
Sogawa K, Takano S, Iida F, Satoh M, Tsuchida S, Kawashima Y, Yoshitomi H, Sanda A, Kodera Y, Takizawa H, Mikata R, Ohtsuka M, Shimizu H, Miyazaki M, Yokosuka O, Nomura F.
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Journal Title
Br J Cancer.
Volume: 115
Issue: 8
Pages: 949-956
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients.2016
Author(s)
Kobayashi S, Hoshino T, Hiwasa T, Satoh M, Rahmutulla B, Tsuchida S, Komukai Y, Tanaka T, Matsubara H, Shimada H, Nomura F, Matsushita K
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Journal Title
Oncotarget
Volume: 7
Issue: 50
Pages: 82493-82503
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fibrinogen alpha C chain 5.9 kDa fragment (FIC5.9), a biomarker for various pathological conditions, is produced in post-blood collection by fibrinolysis and coagulation factors2016
Author(s)
Kikuchi W, Nishimura M, Kuga T, Tsuchida S, Saito T, Satoh M, Noda K, Kodera Y, Tomonaga T, Nomura F
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Journal Title
Clinical Proteomics
Volume: 13
Issue: 1
Pages: 27-27
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] MALDI Biotyperを用いたrapid BACproIIの有用性に関する検討2017
Author(s)
土田 祥央, 村田 正太, 齊藤 知子, 宮部 安規子, 瀬川 俊介, 佐海 知子, 上原 麻美, 中村 恵海, 渡邊 正治, 芦澤 一穂, 寺田 崇, 佐藤 守, 西村 基, 松下 一之, 野村 文夫
Organizer
第28回日本臨床微生物学会総会
Place of Presentation
長崎ブリックホール(長崎県・長崎市)
Year and Date
2017-01-20
Related Report
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[Presentation] 37mmクオリティモニターを用いたMALDI-TOF MSによる血液培養ボトルからの迅速細菌同定の検討2017
Author(s)
土田 祥央, 宮部 安規子, 村田 正太, 齊藤 知子, 瀬川 俊介, 佐海 知子, 上原 麻美, 中村 恵海, 渡邊 正治, 曽川 一幸, 滝脇 正貴, 西村 基, 佐藤 守, 松下 一之, 野村 文夫
Organizer
第42回日本医用マススペクトル学会
Related Report
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[Presentation] 血液培養陽性ボトルからの迅速同定におけるrapid BACproの有用性に関する検討2016
Author(s)
村田 正太, 齊藤 知子, 宮部 安規子, 瀬川 俊介, 佐海 知子, 上原 麻美, 中村 恵海, 渡邊 正治, 芦澤 一穂, 寺田 崇, 土田 祥央, 佐藤 守, 西村 基, 野村 文夫, 松下 一之
Organizer
第27回日本臨床微生物学会総会
Place of Presentation
仙台国際センター(宮城県・仙台市)
Year and Date
2016-01-29
Related Report
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[Presentation] 質量分析計による細菌迅速同定を目的とした直接同定用前処理方法の検討2016
Author(s)
芦澤 一穂, 村田 正太, 齊藤 知子, 宮部 安規子, 瀬川 俊介, 佐海 知子, 上原 麻美, 中村 恵海, 渡邊 正治, 土田 祥央, 佐藤 守, 西村 基, 野村 文夫, 松下 一之, 寺田 崇
Organizer
第27回日本臨床微生物学会総会
Place of Presentation
仙台国際センター(宮城県・仙台市)
Year and Date
2016-01-29
Related Report
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