| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Periodontal disease is characterized by the chronic inflammation of tooth supporting tissues and the diseased tooth are extracted in the progression form of the disease.The purpose of this study was to investigate the mechanisms of periodontal regeneration by conditioned medium from periodontal ligament stem cells (PDLSC-CM). It has been found that PDLSC-CM and conditioned medium from immortalized bone marrow-derived mesenchymal stem cells contained wide variety of proteins and they enhanced the formation of microvasculature-like structures when applied onto endotherial cells. Additionally, production of proinflammatory cytokines by monocytes were inhibited in the presence of PDLSC-CM, suggesting the anti-inflammatory function of PDLSC-CM. The transplantation of PDLSC-CM enhaced periodontal regeneration and anti-inflammation and angiogenesis are the potential mechanism underlying the regenerative function of PDLSC-CM.
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