| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Periodontitis is caused by bacterial infection. However, the periodontal tissue destruction and alveolar bone resorption are caused by the host immune responses. Recently it has been reported that interleukin (IL)-17 has important role in autoimmune diseases and inflammatory diseases. Therefore, we focused on IL-17C which is one of the family molecules of IL-17, and attempted to clarify its involvement and role in the pathogenesis of periodontitis. We observed that the gene expression of IL-17C and IL-17RE which is its receptor, in human gingival epithelial cells. And the gene expression of IL-17C increased by bacterial antigen stimulation. This suggested that IL-17C is involved in the pathogenesis of periodontitis.
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