| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, we intended to demonstrate the molecular mechanisms by which periodontal tissue regeneration was enhanced with mesenchymal stem cell transplantation. Then, we conducted experiments to examine hypoxic responses in mesenchymal stem cells and periodontal cells. As a results, osteoblastic differentiation of adipose tissue-derived multi lineage progenitor cells was suppressed in hypoxic condition. In addition, several kinds of extracellular matrices such as PLAP-1, type I collagen and fibronectin were increased in hypoxia while PLAP-1 could regulate hypoxic responses by HIF-1. These results suggested that hypoxia might affect the cellular responses of periodontal cells through extracellular matrices production.
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