Enhancement of stem cell induced-periodontal tissue regeneration by utilizing hypoxia biology
| Project/Area Number |
15K11387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山田 聡 東北大学, 歯学研究科, 教授 (40359849)
村上 伸也 大阪大学, 歯学研究科, 教授 (70239490)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯周組織再生 / 低酸素 / 幹細胞 / 間葉系幹細胞 / 細胞外気質 / 細胞外基質 |
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| Outline of Final Research Achievements |
In this study, we intended to demonstrate the molecular mechanisms by which periodontal tissue regeneration was enhanced with mesenchymal stem cell transplantation. Then, we conducted experiments to examine hypoxic responses in mesenchymal stem cells and periodontal cells. As a results, osteoblastic differentiation of adipose tissue-derived multi lineage progenitor cells was suppressed in hypoxic condition. In addition, several kinds of extracellular matrices such as PLAP-1, type I collagen and fibronectin were increased in hypoxia while PLAP-1 could regulate hypoxic responses by HIF-1. These results suggested that hypoxia might affect the cellular responses of periodontal cells through extracellular matrices production.
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Report
(4 results)
Research Products
(11 results)
