role of melatonin in periodontal disease
| Project/Area Number |
15K11392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HOSOKAWA Ikuko 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (50707908)
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| Co-Investigator(Kenkyū-buntansha) |
中西 正 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (00217770)
細川 義隆 徳島大学, 病院, 講師 (90346601)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯周炎 / メラトニン / MMP-1 / CXCL10 / IL-27 / ケモカイン / TNF-α / MMP |
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| Outline of Final Research Achievements |
We examined the effect of melatonin on CXCL10 and MMP-1 productions from IL-1β-stimulated human periodontal ligament cells (HPDLC) in this study. We found that melatonin could inhibit CXCl10 and MMP-1 producutions from IL-1β-stimulated HPDLC. Therefore, melatonin could the initiation and progression of periodontal disease by controlling chemokine and MMP production in periodontal lesions.
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Report
(4 results)
Research Products
(15 results)
