Experimental pathological study on prevention of periodontitis and periimplantitis caused by drugs

Research Project

Project/Area Number	15K11395
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Periodontology
Research Institution	Nagasaki University
Principal Investigator	HARA Yoshitaka 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100)
Co-Investigator(Kenkyū-buntansha)	鵜飼孝長崎大学, 病院(歯学系), 講師 (20295091) 吉村篤利長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70253680)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	歯周炎 / アタッチメントロス / グリチルリチン酸 / インプラント周囲炎 / glycyrrhetinic acid / ラットインプラント周囲炎発症モデル / 病理組織学的研究 / ラット
Outline of Final Research Achievements	Topical application of GA into the rat gingival sulcus inhibited attachment loss and alveolar bone resorption in LPS- induced experimental periodontitis. The study shows that GA can potentially prevent periodontitis in rats. However, further investigations using randomized clinical trials are required to prove this concept.

Report

(4 results)