Experimental pathological study on prevention of periodontitis and periimplantitis caused by drugs
Project/Area Number |
15K11395
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
|
Research Institution | Nagasaki University |
Principal Investigator |
HARA Yoshitaka 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100)
|
Co-Investigator(Kenkyū-buntansha) |
鵜飼 孝 長崎大学, 病院(歯学系), 講師 (20295091)
吉村 篤利 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70253680)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 歯周炎 / アタッチメントロス / グリチルリチン酸 / インプラント周囲炎 / glycyrrhetinic acid / ラットインプラント周囲炎発症モデル / 病理組織学的研究 / ラット |
Outline of Final Research Achievements |
Topical application of GA into the rat gingival sulcus inhibited attachment loss and alveolar bone resorption in LPS- induced experimental periodontitis. The study shows that GA can potentially prevent periodontitis in rats. However, further investigations using randomized clinical trials are required to prove this concept.
|
Report
(4 results)
Research Products
(1 results)